Serine-Threonine Kinase Receptor Associate Protein (STRAP) Confers Stemness in Neuroblastoma

Autor: Pran K. Datta, Adele P. Williams, Jerry E. Stewart, Raoud Marayati, Laura V. Bownes, Elizabeth A. Beierle, Colin H. Quinn, Juliet L. Easlick, Joseph T. Whitaker
Rok vydání: 2021
Předmět:
Zdroj: Section on Surgery Program.
DOI: 10.1542/peds.147.3_meetingabstract.919-a
Popis: Background: Serine-threonine kinase receptor associated protein (STRAP) is a scaffolding protein that has been implicated in tumor growth and metastasis. The role of STRAP in neuroblastoma (NB) has not been explored. Stem cell-like cancer cells (SCLCCs) are believed to be responsible for tumor cell self-renewal and cancer recurrence. We sought to determine the role of STRAP in neuroblastoma SCLCCs maintenance. …
Databáze: OpenAIRE