High Frequency Functional Ultrasound in Mice
| Autor: | S. SoloukeyTbalvandany, Johannes G. Bosch, Henk-Jan Boele, A.F.W. Vander Steen, W.S. Vanhoogstraten, Sebastiaan K. E. Koekkoek, Geert Leus, C. I. De Zeeuw, N.L. Deoude, Christos Strydis, P. Kruizing, B.S. Generowicz |
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| Přispěvatelé: | Neurosciences, Neurosurgery, Cardiology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physics Brain vasculature business.industry Brain activity and meditation Ultrasound Blood flow high frequency mice brain 03 medical and health sciences symbols.namesake 030104 developmental biology 0302 clinical medicine Cerebral blood flow symbols Neurovascular coupling business Doppler effect Image resolution 030217 neurology & neurosurgery fUS μDoppler Biomedical engineering |
| Zdroj: | 2018 IEEE International Ultrasonics Symposium, IUS 2018, 2018-October 2018 IEEE International Ultrasonics Symposium, IUS 2018 |
| Popis: | Functional ultrasound (fUS) is a relatively new imaging modality to study the brain with a high spatiotemporal resolution and a wide field-of-view. In fUS detailed images of cerebral blood flow and volume are used to derive functional information, as changes in local flow and/or volume may reflect neuronal activation through neurovascular coupling. Most fUS studies so far have been performed in rats. Translating fUS to mice, which is a favorable animal model for neuroscience, pleads for a higher spatial resolution than what has been reported so far. As a consequence the temporal sampling of the blood flow should also be increased in order to adequately capture the wide range in blood velocities, as the Doppler shifts are inversely proportional to the spatial resolution. Here we present our first detailed images of the mouse brain vasculature at high spatiotemporal resolution. In addition we show some early experimental work on tracking brain activity upon local electrical stimulation. |
| Databáze: | OpenAIRE |
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