IgE in childhood asthma: relevance of demographic characteristics and polysensitisation
| Autor: | Michela Silvestri, E. Battistini, Giovanni A. Rossi, Angela Pistorio |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Vital capacity Vital Capacity Nitric Oxide Immunoglobulin E Allergic inflammation Pulmonary function testing Leukocyte Count Forced Expiratory Volume Animals Humans Medicine Eosinophilia Child Asthma biology business.industry Pyroglyphidae Age Factors Allergens respiratory system medicine.disease respiratory tract diseases Eosinophils Breath Tests Child Preschool Pediatrics Perinatology and Child Health Exhaled nitric oxide Immunology biology.protein Salbutamol Female medicine.symptom business Biomarkers medicine.drug |
| Zdroj: | Archives of Disease in Childhood. 95:979-984 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.2009.163667 |
| Popis: | Background Despite the therapeutic efficacy of the anti-IgE monoclonal antibody, the role of IgE in allergic asthma is still a matter of debate. This may be mostly relevant in childhood, where a wide range of total serum (s) IgE levels is often detected. Aim To evaluate whether the relationships between total or allergen-specific sIgE levels and the clinical markers of allergic inflammation and the pulmonary function values might be affected by the demographic characteristics of the patients or by the presence of multiple sensitisations to allergens. Methods 64 asthmatic children sensitised to house dust mites (HDM) were evaluated. The role of age, sex and multiple sensitisations was evaluated by multiple regression model (MRM) analysis. Results Total and HDM-specific sIgE levels (Log) showed similar moderate-to-strong correlations with exhaled nitric oxide (FENO) and blood eosinophilia (Log) (p |
| Databáze: | OpenAIRE |
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