MOLECULAR MIMICRY IN THE PATHOGENESIS OF SPONDYLOARTHROPATHIES. A CRITICAL APPRAISAL OF CROSS-REACTIVITY BETWEEN MICROBIAL ANTIGENS AND HLA-B27
| Autor: | Auli Toivanen, Riitta Lahesmaa, Paavo Toivanen, Timo Möttönen, R. Saario, Kaisa Granfors, Mikael Skurnik |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male musculoskeletal diseases Yersinia Infections Klebsiella pneumoniae Genes MHC Class II Molecular Sequence Data Cross Reactions Yersinia Lymphocyte Activation medicine.disease_cause Arthritis Reactive Cross-reactivity Microbiology Rheumatology Antigen Sequence Homology Nucleic Acid medicine Humans Spondylitis Ankylosing Pharmacology (medical) Amino Acid Sequence Peptide sequence HLA-B27 Antigen Aged Antigens Bacterial Tetrapeptide biology business.industry Yersiniosis Middle Aged medicine.disease biology.organism_classification Molecular mimicry Antibody Formation Immunology Female business Bacterial Outer Membrane Proteins |
| Zdroj: | Rheumatology. 31:221-229 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/31.4.221 |
| Popis: | We describe an amino acid homology between a virulence plasmid encoded outer membrane protein of Yersinia, YadA (previously called Yop1) and HLA-B27. This tetrapeptide is also included in the hexapeptide, earlier found to be identical between Klebsiella nitrogenase and HLA-B27. The synthetic peptide based on the HLA-B27 homologous portion of the YadA does not stimulate lymphocytes obtained from HLA-B27+ patients with Yersinia-triggered reactive arthritis or from controls. One-third of the yersiniosis patients have antibodies against the synthetic peptide. Instead of recognizing the HLA-B27 homologous portion, the antibodies are directed against the left flanking sequence of the synthetic peptide. Similar results were obtained regarding antibody response to Klebsiella nitrogenase derived synthetic peptide included in the panel of controls; the response was not restricted to patients with reactive arthritis nor was it specifically directed against the sequence shared by HLA-B27 and Klebsiella pneumoniae nitrogenase. The present results do not support the role of molecular mimicry or cross-reactive antibodies in the pathogenesis of spondyloarthropathies. |
| Databáze: | OpenAIRE |
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