The interleukin-10 promoter genotype predicts diastolic dysfunction in maintenance hemodialysis patients
| Autor: | Gulcan Abali, Serkan Kahraman, Alper Kirkpantur, Gultekin Genctoy, Bulent Altun, Mustafa Arici, Cetin Turgan |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Systole medicine.medical_treatment Diastole Nutritional Status Blood Pressure Doppler echocardiography Doppler imaging Proinflammatory cytokine Predictive Value of Tests Renal Dialysis Internal medicine Humans Medicine Promoter Regions Genetic Aged Inflammation Heart Failure Diastolic Polymorphism Genetic medicine.diagnostic_test business.industry Albumin Hematology Middle Aged Echocardiography Doppler Interleukin-10 Blood pressure Nephrology Cardiology Kidney Failure Chronic Regression Analysis Female Hemodialysis business |
| Zdroj: | Hemodialysis International. 12:352-361 |
| ISSN: | 1542-4758 1492-7535 |
| DOI: | 10.1111/j.1542-4758.2008.00281.x |
| Popis: | Interleukin-10 (IL-10) predominantly acts as an anti-inflammatory factor. Polymorphisms in the IL-10 gene promoter determine quantitative cytokine production. Doppler echocardiography and tissue Doppler imaging (TDI) are superior to conventional echocardiography to evaluate diastolic dysfunction. The IL-10 gene promoter polymorphism at position (-1082) was studied for its association with conventional and Doppler echocardiographic and TDI parameters in 112 hemodialysis (HD) patients. Blood pressure, serum C-reactive protein (CRP), and albumin levels were also examined for the association study. The genetic association study showed that among the HD patients, there was no difference in the prevalence of systolic and diastolic dysfunction between genotypes on conventional echocardiography. However, using Doppler echocardiography and TDI, high producers for the IL-10 -1082 promoter (-1082/GG) have higher E velocities, E/A values, lateral, and septal E' velocities and a lower isovolumic ventricular relaxation time than low (-1082/AA) and intermediate producers (-1082/GA). Significantly higher levels of serum CRP levels and lower plasma albumin levels were found in low and intermediate producers for the IL-10 -1082 promoter than high producers. The IL-10 genotype may balance the effects of inflammatory cytokines on the myocardium and may be a determinant of LV function in HD patients. |
| Databáze: | OpenAIRE |
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