Absolute Bioavailability, Tissue Distribution, and Excretion of Erinacine S in Hericium erinaceus Mycelia
| Autor: | Ting-Wei Lin, Chia-Feng Kuo, Chin-Chu Chen, I-Chen Li, Jun-Hao Hu, Wan-Ping Chen, Li-Ya Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Erinacine
tissue distribution Pharmaceutical Science Pharmacology Analytical Chemistry Excretion lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry Oral administration Drug Discovery medicine Hericium erinaceus mycelia Large intestine Physical and Theoretical Chemistry 030304 developmental biology Erinacine S 0303 health sciences Erinaceus biology Organic Chemistry biology.organism_classification Small intestine Bioavailability medicine.anatomical_structure chemistry Chemistry (miscellaneous) Molecular Medicine excretion bioavailability 030217 neurology & neurosurgery Hericium erinaceus |
| Zdroj: | Molecules Volume 24 Issue 8 Molecules, Vol 24, Iss 8, p 1624 (2019) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24081624 |
| Popis: | Erinacine S, so far known to have been produced only in Hericium erinaceus mycelia, has just recently been discovered and is able to reduce amyloid plaque growth and improve neurogenesis in aged brain of rats. However, few investigations have been conducted on the absorption, distribution, and excretion study of Erinacine S. This study aimed to investigate the absolute bioavailability, tissue distribution, and excretion of Erinacine S in H. Erinaceus mycelia in eight-week old Sprague-Dawley rats. After oral administration and intravenous administration of 2.395 g/kg body weight of the H. erinaceus mycelia extract (equivalent to 50 mg/kg body weight Erinacine S) and 5 mg/kg of Erinacine S, respectively, the absolute bioavailability was estimated as 15.13%. In addition, Erinacine S was extensively distributed in organs such as brain, heart, lung, liver, kidney, stomach, small intestine, and large intestine. The maximum concentration of Erinacine S was observed in the stomach, 2 h after the oral administration of H. erinaceus mycelia extract, whereas the maximum amount of Erinacine S found in other tissues were seen after 8 h. Total amount of unconverted Erinacine S eliminated in feces and urine in 24 h was 0.1% of the oral dosage administrated. This study is the first to show that Erinacine S can penetrate the blood&ndash brain barrier of rats and thus support the development of H. erinaceus mycelia, for the treatment of neurological diseases. |
| Databáze: | OpenAIRE |
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