Biological features of the clone involved in primary amyloidosis (AL)
| Autor: | Simona Casarini, Edoardo Ascari, M. Colli Vignarelli, Vittorio Perfetti, Giampaolo Merlini |
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| Rok vydání: | 2001 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Amyloid business.industry Amyloidosis Plasma cell dyscrasia Hematology medicine.disease Immunoglobulin light chain Immunophenotyping medicine.anatomical_structure Oncology Karyotyping Herpesvirus 8 Human Monoclonal medicine AL amyloidosis Humans Clone (B-cell biology) business B cell |
| Zdroj: | Leukemia. 15:195-202 |
| ISSN: | 1476-5551 0887-6924 |
| Popis: | Primary light chain-associated amyloidosis (AL) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). It is the most common form of systemic amyloidosis in Western countries and is rapidly fatal. Knowledge of the pathobiology of the underlying B cell clone is of primary importance for the design and optimization of therapeutic strategies. |
| Databáze: | OpenAIRE |
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