N6-methyladenosine RNA modification and its interaction with regulatory non-coding RNAs in colorectal cancer
| Autor: | Siyi Xu, Yiyi Ren, Lihong Yin, Yanqiu Zhang, Yiling Ge, Tong Liu, Geyu Liang, Yuepu Pu, Yanlu Feng, Chuntao Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Adenosine
RNA Untranslated Colorectal cancer Computational biology Review Biology Methylation chemistry.chemical_compound RNA modification medicine Biomarkers Tumor Animals Humans Molecular Targeted Therapy RNA Messenger Molecular Biology Regulation of gene expression Mechanism (biology) Cell Biology RNA Circular medicine.disease Gene Expression Regulation Neoplastic MicroRNAs chemistry RNA Long Noncoding N6-Methyladenosine Colorectal Neoplasms Function (biology) |
| Zdroj: | RNA Biol |
| ISSN: | 1555-8584 |
| Popis: | As one of the most common forms of RNA modification, N6-methyladenosine (m6A) RNA modification has attracted increasing research interest in recent years. This reversible RNA modification added a new dimension to the post-transcriptional regulation of gene expression. In colorectal cancer (CRC), the role of m6A modification has been extensively studied, not only on mRNAs but also on non-coding RNAs (ncRNAs). In the present review, we depicted the role of m6A modification in CRC, systematically elaborate the interaction between m6A modification and regulatory ncRNAs in function and mechanism. Moreover, we discussed the potential applications in clinical. |
| Databáze: | OpenAIRE |
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