Differential effects of CD28 costimulation upon cytokine production by CD4+ and CD8+ T cells
| Autor: | David N. Ernst, Rosemary Rochford, Anaira C. Clavo, Monte V. Hobbs, James E. Riggs |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Time Factors medicine.medical_treatment T cell Immunology CD8-Positive T-Lymphocytes CCL5 Mice Interleukin 21 CD28 Antigens T-Lymphocyte Subsets medicine Animals Immunology and Allergy Cytotoxic T cell RNA Messenger IL-2 receptor Mice Inbred BALB C Chemistry CD28 Hematology Molecular biology Hyaluronan Receptors Cytokine medicine.anatomical_structure Cytokines Cell Division CD8 |
| Zdroj: | Immunobiology. 209:513-522 |
| ISSN: | 0171-2985 |
| DOI: | 10.1016/j.imbio.2004.05.004 |
| Popis: | The impact of CD28 ligation upon CD4 + and CD8 + T lymphocyte proliferation and cytokine production was assessed. Although costimulation increased the proliferative response of both T cell subsets, cytokine production was most markedly increased in the CD4 + subset, as evidenced by a 40-fold increase in interleukin-2 (IL-2), a 14-fold increase in interleukin-3 (IL-3) and 5-fold increases in interferon γ and GM-colony-stimulating factor (CSF) production. The CD8 + T cell response to CD28 ligation was less marked, maxima being a 5-fold increase in IL-2 production and 2-fold increases in IL-3 and GM-CSF production. Resolution of CD4 + and CD8 + T cells into their CD44 lo (naive) and CD44 hi (memory/effector) subsets revealed that naive CD4 + T cells were the most CD28-responsive subsets. CD28-mediated costimulation promotes distinct differentiation programs in CD4 + versus CD8 + T cells. |
| Databáze: | OpenAIRE |
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