A dynamic, embodied paradigm to investigate the role of serotonin in decision-making

Autor: Derrik Espinoza Asher, Alexis B. Craig, Andrew eZaldivar, Alyssa A. Brewer, Jeffrey L Krichmar
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Frontiers in Integrative Neuroscience
Frontiers in Integrative Neuroscience, Vol 7 (2013)
Asher, Derrik E; Craig, Alexis B; Zaldivar, Andrew; Brewer, Alyssa A; & Krichmar, Jeffrey L. (2013). A dynamic, embodied paradigm to investigate the role of serotonin in decision-making. Frontiers in Integrative Neuroscience, 7. doi: 10.3389/fnint.2013.00078. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/95k4g3pd
ISSN: 1662-5145
DOI: 10.3389/fnint.2013.00078
Popis: Serotonin (5-HT) is a neuromodulator that has been attributed to cost assessment and harm aversion. In this review, we look at the role 5-HT plays in making decisions when subjects are faced with potential harmful or costly outcomes. We review approaches for examining the serotonergic system in decision-making. We introduce our group’s paradigm used to investigate how 5-HT affects decision-making. In particular, our paradigm combines techniques from computational neuroscience, socioeconomic game theory, human-robot interaction, and Bayesian statistics. We will highlight key findings from our previous studies utilizing this paradigm, which helped expand our understanding of 5-HT’s effect on decision-making in relation to cost assessment. Lastly, we propose a cyclic multidisciplinary approach that may aid in addressing the complexity of exploring 5-HT and decision-making by iteratively updating our assumptions and models of the serotonergic system through exhaustive experimentation.
Databáze: OpenAIRE