Concanavalin-A binding sites, pemphigus antigens, and ?2microglobulin in epidermal hyperproliferation, premalignant and malignant lesions
| Autor: | Regine Bolling, Hedwig Patyk, G. Mahrle |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Beta-Globulins Fluorescent Antibody Technique Dermatology Biology Immunofluorescence Antigen Psoriasis Biopsy Concanavalin A medicine Humans Antigens Binding Sites integumentary system medicine.diagnostic_test Beta-2 microglobulin Keratosis General Medicine medicine.disease Basal cell epithelioma Pemphigus Solar keratosis Carcinoma Squamous Cell beta 2-Microglobulin Precancerous Conditions |
| Zdroj: | Archives of Dermatological Research. 274:85-92 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/bf00510362 |
| Popis: | Three cell surface parameters of epidermal cells have been studied by immunofluorescence, pemphigus antigens, concanavalin-A binding sugars, and beta 2 microglobulin. Biopsy specimens were taken from a total of 59 patients with psoriasis, seborrheic and solar keratosis, squamous cell carcinoma, and basal cell epithelioma. We found a loss of demonstrability of all parameters in dedifferentiated tumors or tumor areas in squamous cell carcinoma, premonitory changes in solar keratosis, and no changes in seborrheic keratosis. In the psoriatic epidermis a granular redistribution of the cell surface parameters was occasionally observed in circumscribed areas of the epidermis. A selective loss of the demonstrability of beta 2 microglobulin was the prominent feature in basal cell epithelioma. Our findings demonstrate that the alterations of the cell surface differ in malignant and premalignant skin tumors, in basal cell epithelioma, and in benign psoriatic hyperplasia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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