Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy
| Autor: | Zhijun Bao, Wen Tan, Jiao Sun, Xudan Lou, Yanyuan Tu, Haidong Wang, Cuiping Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Sleep Wake Disorders medicine.medical_specialty endocrine system Science Physiology CLOCK Proteins Article Thyroid cancer Gene expression analysis medicine Humans Circadian rhythm Thyroid Neoplasms Thyroid Nodule Aged Multidisciplinary business.industry Thyroid Age Factors ARNTL Transcription Factors Nodule (medicine) Middle Aged medicine.disease Sleep in non-human animals Circadian Rhythm PER2 Thyroid diseases Gene Expression Regulation Neoplastic medicine.anatomical_structure Risk factors Immunohistochemistry Medicine Histopathology Female medicine.symptom business Sleep |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | To study the alterations of sleep quality and circadian rhythm genes expressions upon elderly thyroid nodule patients, the risk factors associated with thyroid malignancies, and the potential relationship involved. The elderly people enrolled in our study were divided into three groups according to the thyroid histopathology: malignant nodule group, benign nodule group, and normal group, and the clinical data and sleep quality were collected. Among the patients of surgery, 56 fresh thyroid tissues were collected for real-time PCR, immunohistochemistry and western blotting analysis of CLOCK, BMAL1, CRYs and PERs. Poor sleep quality, sleep latency and daytime dysfunction were the independent risk factors of malignant nodule after adjusted by other impacts. The expression levels of CLOCK, BMAL1 and PER2 in thyroid malignant group were significantly higher than benign and normal groups, while CRY2 was decreased, p |
| Databáze: | OpenAIRE |
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