OXIDATIVE STRESS IN DIABETES-INDUCED CANCER:MASTER PLAYERS IN A NEW COMPLICATION
| Autor: | ASSAAD, Antoine Eid |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| DOI: | 10.18143/jisanh_v3i1_932 |
| Popis: | Both diabetes and cancer are prevalent diseases whose incidence is increasing worldwide. Epidemiological studies provide strong evidence that subjects with diabetes are at significantly higher risk of developing many forms of cancer and especially solid tumors. In addition to pancreatic and breast cancer, the incidence of colorectal cancer is increased in type 2 diabetes. While diabetes and especially type 2 diabetes and cancer share many risk factors, the biological links between the two diseases are poorly characterized. Our group has identified new sources of reactive oxygen species (ROS) that play a central role in diabetes-induced cancer. Our hypothesis is that inactivation of AMPK and tuberin and activation of the mTOR pathway through ROS dependant mechanisms in diabetes results in downregulation of the DNA repair enzyme 8-oxoG-DNA glycosylase (OGG1) and accumulation of 8-oxodG. 8-OxodG accelerating tumor development and tumor burden. Journal of International Society of Antioxidants in Nutrition & Health, Vol 3, No 1 (2016): Special Volume of ISANH Conference/Congress |
| Databáze: | OpenAIRE |
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