Trans-endothelial and trans-epithelial transfer of lactoferrin into the brain through BBB and BCSFB in adult rats
| Autor: | Hirohiko Shimizu, Kunio Ando, Takashi Takeuchi, Nao Kamemori, Etsumori Harada, Mariko Miyabayashi, Akihiko Sugiyama, Hiroshi Kitagawa |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Ependymal Cell General Veterinary biology Lactoferrin business.industry Vesicle Endothelial Cells Biological Transport Immunohistochemistry Rats Cerebrospinal fluid Blood-Brain Barrier Bovine lactoferrin Choroid Plexus biology.protein medicine Animals Choroid plexus Brain matter business |
| Zdroj: | The Journal of veterinary medical science. 70(3) |
| ISSN: | 0916-7250 |
| Popis: | The transportation of intravenously administered bovine lactoferrin (bLF) into the cerebrospinal fluid (CSF) was immunohistochemically investigated in adult rats. Administered bLF was detected in the vesicular membranes of endothelial cells in cerebral blood vessels 10 min after the infusion. Numerous immunoreactive small vesicles were also detected at the ependymal cells in the choroid plexus. Moreover, the bLF concentration in the CSF was significantly increased at 1-2 hr after the intravenous infusion of bLF (10 or 30 mg/kg). These findings clearly demonstrate that LF is possibly transported into the brain matter even in adult animals. |
| Databáze: | OpenAIRE |
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