Risk Prediction of Cervical Cancer and Precancers by Type-Specific Human Papillomavirus: Evidence from a Population-Based Cohort Study in China
Autor: | Li Dong, Ruimei Feng, Qian Zhang, Li Zhang, Shang-Ying Hu, Xuelian Zhao, You-Lin Qiao, Fang-Hui Zhao, Xun Zhang |
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Rok vydání: | 2017 |
Předmět: |
Oncology
Adult Risk Cancer Research medicine.medical_specialty China Genotype Population Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Cohort Studies 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans 030212 general & internal medicine Papillomaviridae education Gynecology Colposcopy Cervical cancer education.field_of_study medicine.diagnostic_test biology business.industry Papillomavirus Infections virus diseases Cancer Middle Aged medicine.disease biology.organism_classification Uterine Cervical Dysplasia female genital diseases and pregnancy complications Social Class 030220 oncology & carcinogenesis Cohort Female business Precancerous Conditions Cohort study |
Zdroj: | Cancer prevention research (Philadelphia, Pa.). 10(12) |
ISSN: | 1940-6215 |
Popis: | Risk stratification of human papillomavirus (HPV)-positive women is needed to avoid excessive colposcopy and overtreatment in cervical cancer screening. We aimed to evaluate the predictive value of type-specific HPV in detecting cervical cancer and precancers in a Chinese population–based cohort and provide evidence of HPV genotyping to triage HPV-positive women. We typed all Hybrid Capture 2–positive cytologic samples of 1,742 women in Shanxi Province Cervical Cancer Screening Study cohort. Cumulative risks of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) among HPV-positive women and cumulative detection rates of CIN2+ among general women by type-specific HPV were estimated during the course of 10-year follow-up. HPV 16 and HPV 52 were most prevalent types among the screening population. Ten-year cumulative risk of CIN2+ was 47.5% [95% confidence interval (CI), 31.6–62.3] for HPV 16–positive women and 46.3% (95% CI, 15.3–75.4) for HPV 31–positive women. Ten-year cumulative risks of CIN2+ among HPV 58, 39, 33, 18, and 52 positive women ranged from 34.3% to 12.0% in a decreasing order. CIN2+ risks were found to be positively associated with infection times of the same genotypes of HPV 16, 31, 33, and 58 (all Ptrend < 0.001). Cumulative detection rates of CIN2+ within 10 years were predominantly contributed by HPV 16, 31, and 58. Our results support the risk-based management of HPV-positive women using HPV genotyping and also indicate the significance of including HPV 31 and 58 apart from commonly acknowledged HPV 16 and HPV 18 in achieving better risk stratification. Cancer Prev Res; 10(12); 745–51. ©2017 AACR. |
Databáze: | OpenAIRE |
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