Trefoil factors (TFFs) are increased in bronchioalveolar lavage fluid from patients with chronic obstructive lung disease (COPD)
| Autor: | Helle Andreassen, Steen Seier Poulsen, Niels Erik Viby, Hannelouise Kissow, Lars Thim, Ebba Nexo, Paul Frost Clementsen |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Physiology Biochemistry Severity of Illness Index TFF Pulmonary function testing Cellular and Molecular Neuroscience Pulmonary Disease Chronic Obstructive Endocrinology Bronchoscopy Medicine Humans education Asthma Aged Aged 80 and over education.field_of_study COPD Lung business.industry Hypersecretion Mucin Trefoil factor 2 Cancer Middle Aged medicine.disease Obstructive lung disease medicine.anatomical_structure Lung disease Female Trefoil Factor-2 business Peptides Bronchoalveolar Lavage Fluid |
| Zdroj: | Viby, N-E, Nexø, E, Kissow, H, Andreassen, H, Clementsen, P, Thim, L & Poulsen, S S 2015, ' Trefoil factors (TFFs) are increased in bronchioalveolar lavage fluid from patients with chronic obstructive lung disease (COPD) ', Peptides, vol. 63, pp. 90-95 . https://doi.org/10.1016/j.peptides.2014.09.026 |
| ISSN: | 1873-5169 |
| Popis: | Trefoil factors (TFFs) 1, 2 and 3 are small polypeptides that are co-secreted with mucin throughout the body. They are up-regulated in cancer and inflammatory processes in the gastrointestinal system, where they are proposed to be involved in tissue regeneration, proliferation and protection. Our aim was to explore their presence in pulmonary secretions and to investigate whether they are up-regulated in pulmonary diseases characterized by mucin hypersecretion. Bronchioalveolar lavage fluid was obtained from 92 individuals referred to bronchoscopy. The patients were grouped according to diagnosis and pulmonary function. The concentrations of TFF1, TFF2 and TFF3 were measured by ELISA. All three peptides were detected in bronchioalveolar lavage fluid. Patients with chronic obstructive pulmonary disease had concentrations two to three times above the levels in the healthy reference group, and patients with pulmonary malignancies had concentrations of TFF1 and TFF2 three times that of the reference group. The results suggest that TFFs are involved in tissue regeneration, proliferation and protection in lung diseases. Trefoil factors (TFFs) 1, 2 and 3 are small polypeptides that are co-secreted with mucin throughout the body. They are up-regulated in cancer and inflammatory processes in the gastrointestinal system, where they are proposed to be involved in tissue regeneration, proliferation and protection. Our aim was to explore their presence in pulmonary secretions and to investigate whether they are up-regulated in pulmonary diseases characterized by mucin hypersecretion. Bronchioalveolar lavage fluid was obtained from 92 individuals referred to bronchoscopy. The patients were grouped according to diagnosis and pulmonary function. The concentrations of TFF1, TFF2 and TFF3 were measured by ELISA. All three peptides were detected in bronchioalveolar lavage fluid. Patients with chronic obstructive pulmonary disease had concentrations two to three times above the levels in the healthy reference group, and patients with pulmonary malignancies had concentrations of TFF1 and TFF2 three times that of the reference group. The results suggest that TFFs are involved in tissue regeneration, proliferation and protection in lung diseases. |
| Databáze: | OpenAIRE |
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