The role of enzyme induction on metabolite formation of bis(2-methoxyethyl) ether in the rat
| Autor: | Weigel Ww, Begley Kb, Richards De, Kenneth L. Cheever |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
0301 basic medicine
Male Methyl Ethers Health Toxicology and Mutagenesis Metabolite 010501 environmental sciences Acetates Toxicology 01 natural sciences Excretion 03 medical and health sciences Acetic acid chemistry.chemical_compound Cytochrome P-450 Enzyme System medicine Animals Enzyme inducer Biotransformation 0105 earth and related environmental sciences Chromatography 030102 biochemistry & molecular biology biology Dose-Response Relationship Drug Public Health Environmental and Occupational Health Diglyme Drug Synergism Rats Inbred Strains Rats Hexobarbital chemistry Biochemistry Enzyme Induction Phenobarbital biology.protein Ethylene Glycols Sleep medicine.drug Toxicant |
| Zdroj: | Toxicology and industrial health. 5(3) |
| ISSN: | 0748-2337 |
| Popis: | The effect of enzyme induction on the metabolism of the reproductive toxicant bis (2-methoxyethyl) ether (diglyme) was studied in male Sprague-Dawley rats. Rats were given either daily doses of diglyme at 5.1 mmol/kg body wt. by gavage or 0.1% (w/v)phenobarbital (PB) in the drinking water for 22 consecutive days. In one study, a significant reduction in the hexobarbital sleeping time was determined for rats pretreated with diglyme or PB in comparison with that determined for naive rats. In a second study, naive and pretreated rats given single oral doses of14C-diglyme at 5.1 mmol/kg body wt. showed similar urinary 14C excretion patterns. Urinary metabolites were separated and quantified by hplc to evaluate the influence of pretreatment with either diglyme or PB on the 14C-diglyme urinary metabolite profile. The amount of (2-methoxyethoxy) acetic acid, the principal metabolite, was similar for rats given no pretreatment and for rats pretreated with either diglyme or PB. However, both pretreatments resulted in significant increases in the formation of methoxyacetic acid, a recognized reproductive toxicant. |
| Databáze: | OpenAIRE |
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