Myocardial perfusion and regression of coronary artery disease in patients on a regimen of intensive physical exercise and low fat diet
| Autor: | Martin Grunze, Klaus Hauer, Günter Schlierf, Rainer Hambrecht, Wolfgang Kubler, Gerhard Schuler, Sabine Methfessel |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Cardiac Catheterization medicine.medical_specialty medicine.medical_treatment Coronary Disease Physical exercise Coronary Angiography Scintigraphy Coronary artery disease chemistry.chemical_compound Risk Factors Coronary Circulation Internal medicine medicine Humans Radionuclide Imaging Cardiac catheterization medicine.diagnostic_test Cholesterol business.industry Remission Induction Rehabilitation Angiography Digital Subtraction Middle Aged medicine.disease Combined Modality Therapy Coronary Vessels Dietary Fats Regression Exercise Therapy Thallium Radioisotopes Regimen chemistry Angiography Physical Endurance Cardiology Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | Journal of the American College of Cardiology. 19:34-42 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/0735-1097(92)90048-r |
| Popis: | This intervention program tested the applicability and effects of intensive physical exercise and a low fat diet on progression of coronary atherosclerotic lesions and stress-induced myocardial ischemia in patients with stable angina pectoris. Eighteen patients participated in this program for 1 year; they consumed a low fat, low cholesterol diet (less than 20 energy % fat, cholesterol less than 200 mg/day) and exercised for greater than 3 h/week. Change in coronary morphology was assessed by angiography and digital image processing; stress-induced myocardial ischemia was measured by thallium-201 scintigraphy. Results were compared with those in patients receiving "usual care." In the intervention group, significant regression of coronary atherosclerotic lesions was noted in 7 of the 18 patients; no change or progression was present in 11 patients. In patients receiving usual care, regression was detected in only 1, with no change or progression in 11 patients (different from intervention, p less than 0.05). There was a significant reduction in stress-induced myocardial ischemia, which was not limited to patients with regression of coronary atherosclerotic lesions. Thus, regular physical exercise and a low fat diet may retard progression of coronary artery disease; however, improvement of myocardial perfusion may be achieved independently from regression of stenotic lesions. |
| Databáze: | OpenAIRE |
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