Oral and uro-vaginal intra-amniotic infection in women with preterm delivery: A case-control study
| Autor: | Diana Marcela Castillo, Daniela Loyo, Daniel Montenegro, Luz Amparo Gómez, Luis F. Borda, Gloria Inés Lafaurie, Yineth Neuta |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Mycoplasma hominis Chorioamnionitis medicine.disease_cause Gastroenterology 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Placenta Medicine Humans Porphyromonas gingivalis Periodontitis biology business.industry Infant Newborn 030206 dentistry General Medicine medicine.disease biology.organism_classification Amniotic Fluid medicine.anatomical_structure 030220 oncology & carcinogenesis Case-Control Studies Premature Birth Female Fusobacterium nucleatum business Premature rupture of membranes Ureaplasma urealyticum |
| Zdroj: | Journal of investigative and clinical dentistry. 10(2) |
| ISSN: | 2041-1626 |
| Popis: | Aim The aim of the present study was to establish the association between the presence of oral and uro-vaginal microorganisms in the placental membrane and preterm delivery (PTD), the premature rupture of membranes (PRM), and the clinical signs of intra-amniotic infection. Methods Eighty-four women with PTD and 127 women with delivery at term were assessed for the PRM, clinical signs of intra-amniotic infection, and the presence of periodontitis. Twenty-seven microorganisms were identified in the placental tissue using nested polymerase chain reaction (PCR). Porphyromonas gingivalis (P. gingivalis) was quantified by droplet digital PCR. Results The prevalence of microorganisms was 9.47% (20/211). P. gingivalis was the most prevalent (12/211, 5.68%). Mycoplasma hominis, Ureaplasma urealyticum, Staphylococcus spp, and Fusobacterium nucleatum were isolated at a very low frequency in the placenta. Candida albicans was associated with PTD (P = 0.027). Periodontitis was associated with clinical signs of infection (odds ratio [OR] = 3.8, 95% confidence interval [CI]: 1.28-13.5) and with PTD (OR = 1.99; 95% CI: 1.07-3.72). Conclusion The presence of P. gingivalis in the placenta was not associated with perinatal complications. Detecting microorganisms in the placenta by nested PCR is not relevant, as it has a poor association with clinical variables that establish the diagnosis of chorioamnionitis. However, periodontitis was associated with the clinical signs of intra-amniotic infection and PTD. |
| Databáze: | OpenAIRE |
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