Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing
Autor: | Paula Ludovico, Belém Sampaio-Marques, William C. Burhans |
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Přispěvatelé: | Universidade do Minho |
Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
autophagy
Chronological lifespan Applied Microbiology media_common.quotation_subject Saccharomyces cerevisiae ved/biology.organism_classification_rank.species yeast lifespan ageing Biochemistry Genetics and Molecular Biology (miscellaneous) Microbiology Applied Microbiology and Biotechnology replicative Virology Mitophagy Autophagy Genetics replicative lifespan Model organism Molecular Biology lcsh:QH301-705.5 media_common Science & Technology Nutrient-sensing pathways biology ved/biology Longevity Cell Biology biology.organism_classification chronological lifespan Yeast Cell biology Ageing mitophagy lcsh:Biology (General) ageing Proteome Parasitology nutrient-sensing pathways Replicative lifespan Biogenesis |
Zdroj: | Microbial Cell, Vol 1, Iss 4, Pp 118-127 (2014) Microbial Cell Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
ISSN: | 2311-2638 |
Popis: | Ageing is a complex and multi-factorial process that results in the progressive accumulation of molecular alterations that disrupt different cellular functions. The budding yeast Saccharomyces cerevisiae is an important model organism that has significantly contributed to the identification of conserved molecular and cellular determinants of ageing. The nutrient-sensing pathways are well-recognized modulators of longevity from yeast to mammals, but their downstream effectors and outcomes on different features of ageing process are still poorly understood. A hypothesis that is attracting increased interest is that one of the major functions of these “longevity pathways” is to contribute to the maintenance of the proteome during ageing. In support of this hypothesis, evidence shows that TOR/Sch9 and Ras/PKA pathways are important regulators of autophagy that in turn are essential for healthy cellular ageing. It is also well known that mitochondria homeostasis and function regulate lifespan, but how mitochondrial dynamics, mitophagy and biogenesis are regulated during ageing remains to be elucidated. This review describes recent findings that shed light on how longevity pathways and metabolic status impact maintenance of the proteome in both yeast ageing paradigms. These findings demonstrate that yeast remain a powerful model system for elucidating these relationships and their influence on ageing regulation. This work was supported by Fundacao para a Ciencia e Tecnologia (FCT, Portugal) and COMPETE/QREN/EU (PTDC/BIAMIC/114116/2009). BSM is supported by the fellowship SFRH/BPD/90533/2012 funded by the Fundacao para a Ciencia e Tecnologia (FCT, Portugal). William C. Burhans acknowledges a grant from the Roswell Park Alliance Foundation. The authors apologize for not citing the pioneering work of many colleagues, as this was not intended as an exhaustive review. |
Databáze: | OpenAIRE |
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