Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy
| Autor: | Yin Cai, Xiaodong Ye, Zhengyuan Xia, Vidya Kandula, Michael G. Irwin, Ramoji Kosuru |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system DNA Repair Diabetic Cardiomyopathies Telomere-Binding Proteins Inflammation Computational biology Review Biology medicine.disease_cause Shelterin Complex 03 medical and health sciences Mice Diabetic cardiomyopathy medicine diabetic cardiomyopathy Animals Humans Molecular Biology Therapeutic strategy Genetics Rap1 Molecular signaling Protein level Telomere Homeostasis Cell Biology DNA Telomere medicine.disease enzymes and coenzymes (carbohydrates) Oxidative Stress 030104 developmental biology Gene Expression Regulation inflammation medicine.symptom metabolism Oxidative stress Metabolic Networks and Pathways Developmental Biology Protein Binding Signal Transduction |
| Zdroj: | Cell Cycle |
| ISSN: | 1551-4005 |
| Popis: | Mammalian Rap1, the most conserved telomere-interacting protein, beyond its role within nucleus for the maintenance of telomeric functions, is also well known for its pleiotropic functions in various physiological and pathological conditions associated with metabolism, inflammation and oxidative stress. For all these, nowadays Rap1 is the subject of critical investigations aimed to unveil its molecular signaling pathways and to scrutinize the applicability of its modulation as a promising therapeutic strategy with clinical relevance. However, the underlying intimate mechanisms of Rap1 are not extensively studied, but any modulation of this protein level has been associated with pathologies like inflammation, oxidative stress and deregulated metabolism. This is considerably important in light of the recent discovery of Rap1 modulation in diseases like cancer and cardiac metabolic disorders. In this review, we focus on both the telomeric and nontelomeric functions of Rap1 and its modulation in various health risks, especially on the heart. |
| Databáze: | OpenAIRE |
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