Winter is coming: Regulation of cellular metabolism by enzyme polymerization in dormancy and disease
| Autor: | Rosa María López Cabezas, Juha Saarikangas, Kristopher Montrose, Jurgita Paukštytė |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nutrient sensing Biology Cell Physiological Phenomena Polymerization 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Biosynthesis Animals Humans Disease chemistry.chemical_classification Catabolism Cell Biology Metabolism Enzymes Cell biology Metabolic pathway 030104 developmental biology Enzyme chemistry Cytoplasm 030220 oncology & carcinogenesis Dormancy Metabolic Networks and Pathways |
| Zdroj: | Experimental Cell Research. 397:112383 |
| ISSN: | 0014-4827 |
| DOI: | 10.1016/j.yexcr.2020.112383 |
| Popis: | Metabolism feeds growth. Accordingly, metabolism is regulated by nutrient-sensing pathways that converge growth promoting signals into biosynthesis by regulating the activity of metabolic enzymes. When the environment does not support growth, organisms invest in survival. For cells, this entails transitioning into a dormant, quiescent state (G0). In dormancy, the activity of biosynthetic pathways is dampened, and catabolic metabolism and stress tolerance pathways are activated. Recent work in yeast has demonstrated that dormancy is associated with alterations in the physicochemical properties of the cytoplasm, including changes in pH, viscosity and macromolecular crowding. Accompanying these changes, numerous metabolic enzymes transition from soluble to polymerized assemblies. These large-scale self-assemblies are dynamic and depolymerize when cells resume growth. Here we review how enzyme polymerization enables metabolic plasticity by tuning carbohydrate, nucleic acid, amino acid and lipid metabolic pathways, with particular focus on its potential adaptive value in cellular dormancy. |
| Databáze: | OpenAIRE |
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