Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial

Autor: Corneel Coens, Hans-Henning Flechtner, Carolyn C. Gotay, Jolie Ringash, Divine E. Ediebah, Eva Greimel, Andrew Bottomley, Bryce B. Reeve, Efstathios Zikos, Joachim Weis, Madeleine King, M. J. B. Taphoorn, C. Quinten, J. Schmucker von Koch, Egbert F. Smit
Přispěvatelé: Pulmonary medicine, Neurology, CCA - Quality of life
Rok vydání: 2014
Předmět:
Oncology
Risk
Cancer Research
medicine.medical_specialty
Palliative care
Lung Neoplasms
Paclitaxel
Pain
Lower risk
Deoxycytidine
Severity of Illness Index
Quality of life
Internal medicine
Carcinoma
Non-Small-Cell Lung
Surveys and Questionnaires
Severity of illness
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Multicenter Studies as Topic
Interpersonal Relations
Lung cancer
Survival analysis
Proportional Hazards Models
Randomized Controlled Trials as Topic
Proportional hazards model
business.industry
Hazard ratio
Palliative Care
prognostic factors
Nausea
medicine.disease
Prognosis
Survival Analysis
Gemcitabine
humanities
3. Good health
Surgery
health-related quality of life
lung cancer
Clinical Trials
Phase III as Topic
patient-reported outcomes
Quality of Life
Clinical Study
Cisplatin
business
Deglutition Disorders
Zdroj: Ediebah, D E, Coens, C, Zikos, E, Quinten, C, Ringash, J, King, M T, von Koch, J S, Gotay, C, Greimel, E, Flechtner, H, Weis, J, Reeve, B B, Smit, E F, Taphoorn, M J B & Bottomley, A 2014, ' Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial ', British Journal of Cancer, vol. 110, no. 10, pp. 2427-2433 . https://doi.org/10.1038/bjc.2014.208
British Journal of Cancer, 110(10), 2427-2433. Nature Publishing Group
British Journal of Cancer
ISSN: 0007-0920
DOI: 10.1038/bjc.2014.208
Popis: Background: Little is known about whether changes in health-related quality of life (HRQoL) scores from baseline during treatment also predict survival, which we aim to investigate in this study. Methods: We analysed data from 391 advanced non-small-cell lung cancer (NSCLC) patients enrolled in the EORTC 08975 study, which compared palliative chemotherapy regimens. HRQoL was assessed at baseline and after each chemotherapy cycle using the EORTC QLQ-C30 and QLQ-LC13. The prognostic significance of HRQoL scores at baseline and their changes over time was assessed with Cox regression, after adjusting for clinical and socio-demographic variables. Results: After controlling for covariates, every 10-point increase in baseline pain and dysphagia was associated with 11% and 12% increased risk of death with hazard ratios (HRs) of 1.11 and 1.12, respectively. Every 10-point improvement of physical function at baseline (HR=0.93) was associated with 7% lower risk of death. Every 10-point increase in pain (HR=1.08) was associated with 8% increased risk of death at cycle 1. Every 10-point increase in social function (HR=0.91) at cycle 2 was associated with 9% lower risk of death. Conclusions: Our findings suggest that changes in HRQoL scores from baseline during treatment, as measured on subscales of the EORTC QLQ-C30 and QLQ-LC13, are significant prognostic factors for survival.
Databáze: OpenAIRE
Externí odkaz: