The two isomers of a cyclometallated palladium sensitizer show different photodynamic properties in cancer cells

Autor:	Xue-Quan Zhou, Maxime A. Siegler, Sylvestre Bonnet, Anja Busemann, Michael S. Meijer
Rok vydání:	2019
Předmět:	Light chemistry.chemical_element Antineoplastic Agents 010402 general chemistry Photochemistry 01 natural sciences Catalysis Absorbance chemistry.chemical_compound Isomerism Cell Line Tumor Materials Chemistry Organometallic Compounds Humans Density Functional Theory Photosensitizing Agents Singlet Oxygen 010405 organic chemistry Chemistry Singlet oxygen Metals and Alloys General Chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Models Chemical Cancer cell Ceramics and Composites Density functional theory Palladium
Zdroj:	Chemical Communications, 55(32), 4695-4698 Chemical Communications
Popis:	This report demonstrates that changing the position of the carbon–metal bond in a polypyridyl cyclopalladated complex, i.e. going from PdL1 (N^N^C^N) to PdL2 (N^N^N^C), dramatically influences the photodynamic properties of the complex in cancer cells. This effect is primarily attributed to the significantly difference in absorbance and singlet oxygen quantum yields between the two isomers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5a1e0891a50b3ab129b1b9e355fda6 https://hdl.handle.net/1887/80411 Zobrazit plný text záznamu