The Diabetes Prevention Program: baseline characteristics of the randomized cohort. The Diabetes Prevention Program Research Group
| Autor: | S. R. Hoyer, Judith G. Regensteiner, A. M. Jacobsen, P. Casanova, B. Clarke, K. B. Czech, P. O'Hara, M. Kocal, Pamela G. Watson, B. N. Calonge, M. L. Jeffirs, K. A. Smith, K. M. Callaghan, B. M. Kennedy, P. V. Nash, B. Van-Dorsten, J. Mendez, M. Quitingon, A. A. Hebert, H. Seagle, T. Franklin, F. G. Guillory, Donna H. Ryan, M. M. Rozek, K. A. Stepp, B. Harding-Clay, B. J. Goldstein, D. Williamson, J. J. Zachwieja, P. C. Vicknair, David A. Ehrmann, F. L. Greenway, J. Perault, Ronald B. Goldberg, M. Nicosia, P. Rowe, C. M. Mobley, L. E. Melancon, R. M. Hilbrich, R. T. Tulley, W. L. McNabb, M. A. Malloy, D. A. Collins, J. A. Tobian, L. M. Kula, J. T. Mendoza, H. J. Florez, Margaret J. Matulik, J. A. St. Amant, J. Ojito, S. C. Steinke, D. Schweizer, S. Rubtchinsky, A. R. Semenske, C. DeSandre, R. Liberoni, J. Pan, C. M. Champagne, R. P. Donahue, E. Caballero, George A. Bray, K. G. Smith, H. Miettinen, J. P. Burke, E. Tucker, Steven M. Haffner, M. Miller-Stone, James O. Hill, John Spandorfer, L. Testaverde, E. W. Seely, K. E. Lawton, Edward S. Horton, V. McLymont, O. P. Ganda, R. A. Arky, L. Dawson, B. T. Jortberg, I. W. Culbert, L. Murphy, L. A. Mykkanen, B. Eberhardt, J. Calles, A. Giannella, G. Geiger, C. Lark, M. Bryant, K. S. Polonsky, R. Prineas, L. H. Morris, D. A. Sanford, Jennifer C. Lovejoy, S. D. Jackson, Richard F. Hamman, L. L. Smith, C. Pepe, C. F. Oldmixon, Maria G. Montez |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Hypercholesterolemia Blood Pressure Coronary Disease White People Article Body Mass Index Cohort Studies Sex Factors Patient Education as Topic Risk Factors Diabetes mellitus Internal medicine Glucose Intolerance Internal Medicine medicine Humans Advanced and Specialized Nursing Asian business.industry Racial Groups Smoking Hispanic or Latino Middle Aged medicine.disease Lipids United States Black or African American Cholesterol Diabetes Mellitus Type 2 Socioeconomic Factors Baseline characteristics Cohort Indians North American Female business |
| Zdroj: | Diabetes care. 23(11) |
| ISSN: | 0149-5992 |
| Popis: | OBJECTIVE: The Diabetes Prevention Program (DPP) is a 27-center randomized clinical trial designed to evaluate the safety and efficacy of interventions that may delay or prevent development of diabetes in people at increased risk for type 2 diabetes. RESEARCH DESIGN AND METHODS: Eligibility requirements were age > or = 25 years, BMI > or = 24 kg/m2 (> or = 22 kg/m2 for Asian-Americans), and impaired glucose tolerance plus a fasting plasma glucose of 5.3-6.9 mmol/l (or < or = 6.9 mmol for American Indians). Randomization of participants into the DPP over 2.7 years ended in June 1999. Baseline data for the three treatment groups--intensive lifestyle modification, standard care plus metformin, and standard care plus placebo--are presented for the 3,234 participants who have been randomized. RESULTS: Of all participants, 55% were Caucasian, 20% were African-American, 16% were Hispanic, 5% were American Indian, and 4% were Asian-American. Their average age at entry was 51 +/- 10.7 years (mean +/- SD), and 67.7% were women. Moreover, 16% were < 40 years of age, and 20% were > or = 60 years of age. Of the women, 48% were postmenopausal. Men and women had similar frequencies of history of hypercholesterolemia (37 and 33%, respectively) or hypertension (29 and 26%, respectively). On the basis of fasting lipid determinations, 54% of men and 40% of women fit National Cholesterol Education Program criteria for abnormal lipid profiles. More men than women were current or former cigarette smokers or had a history of coronary heart disease. Furthermore, 66% of men and 71% of women had a first-degree relative with diabetes. Overall, BMI averaged 34.0 +/- 6.7 kg/m2 at baseline with 57% of the men and 73% of women having a BMI > or = 30 kg/m2. Average fasting plasma glucose (6.0 +/- 0.5 mmol/l) and HbA1c (5.9 +/- 0.5%) in men were comparable with values in women (5.9 +/- 0.4 mmol/l and 5.9 +/- 0.5%, respectively). CONCLUSIONS: The DPP has successfully randomized a large cohort of participants with a wide distribution of age, obesity, and ethnic and racial backgrounds who are at high risk for developing type 2 diabetes. The study will examine the effects of interventions on the development of diabetes. |
| Databáze: | OpenAIRE |
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