20-HETE and Blood Pressure Regulation
Autor: | Michal L. Schwartzman, Victor Garcia, Cheng-Chia Wu, Tanush Gupta, Yan Ding |
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Rok vydání: | 2014 |
Předmět: |
Endothelium
Blood Pressure Peptidyl-Dipeptidase A Pharmacology Article Natriuresis Renin-Angiotensin System Endothelial activation chemistry.chemical_compound Cytochrome P-450 Enzyme System Hydroxyeicosatetraenoic Acids Renin–angiotensin system Humans Medicine Cytochrome P450 Family 4 Endothelial dysfunction Polymorphism Genetic biology Renal sodium reabsorption business.industry Cytochrome P450 General Medicine medicine.disease Kidney Tubules medicine.anatomical_structure chemistry Hypertension cardiovascular system biology.protein lipids (amino acids peptides and proteins) Arachidonic acid Endothelium Vascular Cytochrome P-450 CYP4A Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
Zdroj: | Cardiology in Review. 22:1-12 |
ISSN: | 1061-5377 |
Popis: | 20-Hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE) is a cytochrome P450 (CYP)-derived omega-hydroxylation metabolite of arachidonic acid. 20-HETE has been shown to play a complex role in blood pressure regulation. In the kidney tubules, 20-HETE inhibits sodium reabsorption and promotes natriuresis, thus, contributing to antihypertensive mechanisms. In contrast, in the microvasculature, 20-HETE has been shown to play a pressor role by sensitizing smooth muscle cells to constrictor stimuli and increasing myogenic tone, and by acting on the endothelium to further promote endothelial dysfunction and endothelial activation. In addition, 20-HETE induces endothelial angiotensin-converting enzyme, thus, setting forth a potential feed forward prohypertensive mechanism by stimulating the renin-angiotensin-aldosterone system. With the advancement of gene sequencing technology, numerous polymorphisms in the regulatory coding and noncoding regions of 20-HETE-producing enzymes, CYP4A11 and CYP4F2, have been associated with hypertension. This in-depth review article discusses the biosynthesis and function of 20-HETE in the cardiovascular system, the pharmacological agents that affect 20-HETE action, and polymorphisms of CYP enzymes that produce 20-HETE and are associated with systemic hypertension in humans. |
Databáze: | OpenAIRE |
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