Clinical features and follow‐up of pediatric patients hospitalized for COVID‐19

Autor: Qifa Song, Feng Tang, Xiaowen Wang, Wanjun Luo, Hong Mei, Hui Li, Jianbo Shao
Rok vydání: 2021
Předmět:
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
Coronavirus disease 2019 (COVID-19)
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
Antiviral Agents
Gastroenterology
White blood cell
Internal medicine
Humans
Medicine
Child
Retrospective Studies
Covid‐19
follow‐up
pediatric patients
Lung
biology
Inhalation
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
business.industry
Infant
Newborn
COVID-19
Infant
Retrospective cohort study
Original Articles
Hospitals
Pediatric
medicine.disease
Confidence interval
COVID-19 Drug Treatment
Hospitalization
Pneumonia
medicine.anatomical_structure
Immunoglobulin M
Child
Preschool
Immunoglobulin G
Pediatrics
Perinatology and Child Health
biology.protein
Female
Original Article
Creatine kinase
coronavirus disease 2019 (COVID‐19)
Tomography
X-Ray Computed
business
Follow-Up Studies
Zdroj: Pediatric Pulmonology
ISSN: 1099-0496
8755-6863
DOI: 10.1002/ppul.25407
Popis: Objective This report summarizes the clinical features and 1‐month follow‐up observations for pediatric patients who were hospitalized with coronavirus disease 2019 (COVID‐19) in Wuhan Women and Children's Hospital. Methods The 1‐month follow‐up data included clinical manifestations and results from serum severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) IgG and IgM tests, reverse‐transcription polymerase chain reaction (RT‐PCR) for SARS‐CoV‐2, lung computed tomography (CT) scans, and laboratory tests. Results Between January 20 and March 15, 2020, 127 patients aged 0–15 years were hospitalized for COVID‐19 treatment, including 3 severe cases and 124 mild or moderate cases. The main therapies included inhalation of aerosolized interferon‐α (122/127) and additional antiviral drugs (28/127). Among the 81 patients who had pneumonia at admission, 35 with right lobe pneumonia had the longest hospital stay (mean 14.5 ± 7 days); 17 with left lobe pneumonia had the highest creatine kinase (154 ± 106 U/L) and creatine kinase myocardial band (CK‐MB, 43 ± 48 U/L) levels; and 29 with bilateral pneumonia had the highest white blood cell counts (8.3 ± 4 × 109/L). Among the 46 patients who were successfully followed up 1 month after discharge, two notable findings were right lobe pneumonia in 22% (95% confidence interval [CI]: 11%–37%) of patients and persistently elevated serum creatine kinase and CK‐MB levels. The median duration of elevated CK‐MB was 45 days. The mean concentrations of serum SARS‐CoV‐2 IgG and IgM in 41 patients were 8.0 ± 7.5 and 98 ± 40 ng/ml, respectively. At follow‐up, four patients retested positive for SARS‐CoV‐2. Conclusions The involvement of different lung lobes in patients with COVID‐19 was associated with variations in the persistence of pneumonia and elevation of CK‐MB levels and body temperature.
Databáze: OpenAIRE
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