Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy
Autor: | Anne Suély Pinto Savall, Tuane Bazanella Sampaio, Simone Pinton, Maria Eduarda Ziani Gutierrez |
---|---|
Rok vydání: | 2017 |
Předmět: |
BDNF
CDNF GDNF NGF neurodegenerative diseases treatment 0301 basic medicine Programmed cell death Central nervous system Context (language use) Disease lcsh:RC346-429 Pathogenesis 03 medical and health sciences Therapeutic approach 0302 clinical medicine Developmental Neuroscience Neurotrophic factors Glial cell line-derived neurotrophic factor medicine lcsh:Neurology. Diseases of the nervous system Invited Review biology 030104 developmental biology medicine.anatomical_structure biology.protein Psychology Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Neural Regeneration Research, Vol 12, Iss 4, Pp 549-557 (2017) Neural Regeneration Research |
ISSN: | 1673-5374 |
Popis: | Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer's disease and Parkinson's disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support - mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor - in the survival, proliferation and maturation of affected neurons in Alzheimer's disease and Parkinson's disease as well as their putative application as new therapeutic approach for these diseases management. |
Databáze: | OpenAIRE |
Externí odkaz: |