Intracranial Electroencephalography Reveals Selective Responses to Cognitive Stimuli in the Periventricular Heterotopias
| Autor: | Aaron Kucyi, Su Liu, Kai Zhang, Jianguo Zhang, Baotian Zhao, Clara Sava-Segal, Josef Parvizi, Babak Razavi, Serdar Akkol, Wenhan Hu, Chao Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Elementary cognitive task Adolescent Neuroimaging Intracranial Electroencephalography Young Adult 03 medical and health sciences Cognition 0302 clinical medicine Periventricular Nodular Heterotopia Humans Medicine Attention Intracranial electrodes Research Articles 030304 developmental biology Brain Mapping 0303 health sciences Resting state fMRI business.industry General Neuroscience Neurophysiology Magnetic Resonance Imaging Electrophysiological Phenomena Electrophysiology Periventricular heterotopia Female Electrocorticography Nerve Net business Neuroscience Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | J Neurosci |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.2785-20.2021 |
| Popis: | Our recent work suggests that non-lesional epileptic brain tissue is capable of generating normal neurophysiological responses during cognitive tasks, which are then seized by ongoing pathologic epileptic activity. Here, we aim to extend the scope of our work to epileptic periventricular heterotopias (PVH) and examine whether the PVH tissue also exhibits normal neurophysiological responses and network-level integration with other non-lesional cortical regions. As part of routine clinical assessment, three adult patients with PVH underwent implantation of intracranial electrodes and participated in experimental cognitive tasks. We obtained simultaneous recordings from PVH and remote cortical sites during rest as well as controlled experimental conditions. In all three subjects (two females), cognitive experimental conditions evoked significant electrophysiological responses in discrete locations within the PVH tissue that were correlated with responses seen in non-epileptic cortical sites. Moreover, the responsive PVH sites exhibited correlated electrophysiological activity with responsive, non-lesional cortical sites during rest conditions. Taken together, our work clearly demonstrates that the PVH tissue may be functionally organized and it may be functionally integrated within cognitively engaged cortical networks despite its anatomic displacement during neurodevelopment.SIGNIFICANCE STATEMENTPeriventricular heterotopias (PVH) are developmentally abnormal brain tissues that frequently cause epileptic seizures. In a rare opportunity to obtain direct electrophysiological recordings from PVH, we were able to show that, contrary to common assumptions, PVH functional activity is similar to healthy cortical sites during a well-established cognitive task and exhibits clear resting state connectivity with the responsive cortical regions. |
| Databáze: | OpenAIRE |
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