Dancing from bottoms up – Roles of the POZ-ZF transcription factor Kaiso in Cancer
| Autor: | Christina C. Pierre, Shawn M. Hercules, Clayton Yates, Juliet M. Daniel |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Poor prognosis Biology Article Metastasis 03 medical and health sciences 0302 clinical medicine Prostate Neoplasms Genetics medicine Animals Humans Prostate cancer incidence Transcription factor Wnt signaling pathway Cancer Myeloid leukemia medicine.disease 3. Good health 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Transcription Factors |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1871:64-74 |
| ISSN: | 0304-419X |
| DOI: | 10.1016/j.bbcan.2018.10.005 |
| Popis: | The POZ-ZF transcription factor Kaiso was discovered two decades ago as a binding partner for p120(ctn). Since its discovery, roles for Kaiso in diverse biological processes (epithelial-to-mesenchymal transition, apoptosis, inflammation) and several signalling pathways (Wnt/β-catenin, TGFβ, EGFR, Notch) have emerged. While Kaiso’s biological role in normal tissues has yet to be fully elucidated, Kaiso has been increasingly implicated in multiple human cancers including colon, prostate, ovarian lung, breast and chronic myeloid leukemia. In the majority of human cancers investigated to date, high Kaiso expression correlates with aggressive tumor characteristics including proliferation and metastasis, and/or poor prognosis. More recently, interest in Kaiso stems from its apparent correlation with racial disparities in breast and prostate cancer incidence and survival outcomes in people of African Ancestry. This review discusses Kaiso’s role in various cancers, and Kaiso’s potential for driving racial disparities in incidence and/or outcomes in people of African ancestry. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect