Genetic diversity and population structure of African village dogs based on microsatellite and immunity-related molecular markers

Autor: Michaela Necesankova, Lorna J. Kennedy, Jan Hlavac, Katerina Albrechtova, Petr Horin, Leona Vychodilova, Mirko Vyskocil, Eva Jánová, Andrei Daniel Mihalca, David Modry
Přispěvatelé: Chiang, Tzen-yuh
Rok vydání: 2017
Předmět:
0106 biological sciences
0301 basic medicine
Heredity
lcsh:Medicine
Population genetics
01 natural sciences
Microsatellite Loci
Gene flow
Major Histocompatibility Complex
Geographical Locations
lcsh:Science
Mammals
education.field_of_study
Principal Component Analysis
Multidisciplinary
Heterozygosity
Geography
Ecology
Pets and Companion Animals
Eukaryota
Europe
Phenotype
Genetic structure
Vertebrates
Microsatellite
Research Article
Genetic Markers
Heterozygote
Ecological Metrics
Animal Types
Population
Biology
010603 evolutionary biology
Polymorphism
Single Nucleotide
03 medical and health sciences
Dogs
Gene Types
Genetic variation
Genetics
Animals
education
Genetic diversity
Evolutionary Biology
Population Biology
lcsh:R
Ecology and Environmental Sciences
Immunity
Organisms
Genetic Variation
Biology and Life Sciences
Species Diversity
Kenya
Lakes
030104 developmental biology
Genetics
Population
Haplotypes
Genetic marker
Evolutionary biology
Genetic Loci
Amniotes
People and Places
lcsh:Q
human activities
Zoology
Software
Population Genetics
Microsatellite Repeats
Zdroj: PLoS ONE
Vychodilova, L, Necesankova, M, Albrechtova, K, Hlavac, J, Modry, D, Janova, E, Vyskocil, M, Mihalca, A D, Kennedy, L J, Horin, P & Chiang, T (ed.) 2018, ' Genetic diversity and population structure of African village dogs based on microsatellite and immunity-related molecular markers ', PLoS ONE, vol. 13, no. 6, pp. e0199506 . https://doi.org/10.1371/journal.pone.0199506
PLoS ONE, Vol 13, Iss 6, p e0199506 (2018)
ISSN: 1932-6203
Popis: The village and street dogs represent a unique model of canine populations. In the absence of selective breeding and veterinary care, they are subject mostly to natural selection. Their analyses contribute to understanding general mechanisms governing the genetic diversity, evolution and adaptation. In this study, we analyzed the genetic diversity and population structure of African village dogs living in villages in three different geographical areas in Northern Kenya. Data obtained for neutral microsatellite molecular markers were compared with those computed for potentially non-neutral markers of candidate immunity-related genes. The neutral genetic diversity was similar to other comparable village dog populations studied so far. The overall genetic diversity in microsatellites was higher than the diversity of European pure breeds, but it was similar to the range of diversity observed in a group composed of many European breeds, indicating that the African population has maintained a large proportion of the genetic diversity of the canine species as a whole. Microsatellite marker diversity indicated that the entire population is subdivided into three genetically distinct, although closely related subpopulations. This genetical partitioning corresponded to their geographical separation and the observed gene flow well correlated with the communication patterns among the three localities. In contrast to neutral microsatellites, the genetic diversity in immunity-related candidate SNP markers was similar across all three subpopulations and to the European group. It seems that the genetic structure of this particular population of Kenyan village dogs is mostly determined by geographical and anthropogenic factors influencing the gene flow between various subpopulations rather than by biological factors, such as genetic contribution of original migrating populations and/or the pathogen-mediated selection. On the other hand, the study of oldest surviving dogs suggested a biological mechanism, i.e. a possible advantage of the overal heterozygosity marked by the the microsatellite loci analyzed.
Databáze: OpenAIRE
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