Construction of a computational mechanical model of bronchi for practical simulation of the optimal positive intrathoracic pressure conditions during general thoracic surgery

Autor:	Suguru Shirai, Hiroshi Kondo, Y. Sakao, Masafumi Kawamura, Tadashi Tanuma, Yuichi Saito, Yoshikane Yamauchi, Hirofumi Uehara, Atsushi Yasuda, T. Yokobori
Rok vydání:	2021
Předmět:	Insufflation medicine.medical_specialty General thoracic surgery Lung Collapse Swine Biomedical Engineering Bronchi Computed tomography 030204 cardiovascular system & hematology Biomaterials 03 medical and health sciences 0302 clinical medicine medicine Animals Computer Simulation Bronchus Lung medicine.diagnostic_test Computational structural mechanics business.industry Thoracic Surgery General Medicine Bronchial occlusion respiratory system respiratory tract diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Hydrodynamics Radiology Tomography X-Ray Computed business
Zdroj:	Bio-Medical Materials and Engineering. 32:333-345
ISSN:	1878-3619 0959-2989
DOI:	10.3233/bme-211228
Popis:	BACKGROUND: Thoracic CO2 insufflation with positive intrathoracic pressure is usually effective during thoracoscopic surgery, however, lung collapse is sometimes insufficient. We hypothesized that inappropriate bronchial collapse might cause this unsuccessful lung collapse. OBJECTIVE: The objective of this study was to construct a computational mechanical model of bronchi for practical simulation to discover the optimal conditions of positive intrathoracic pressure during thoracoscopic surgery. METHODS: Micro-focus high-resolution X-ray computed tomography measurements of lungs from just-slaughtered swine were extracted, and the three-dimensional geometries of the bronchi under pressurized and depressurized conditions were measured accurately. The mechanical properties of the bronchus were also measured. Computational fluid dynamics (CFD) and computational structural mechanics (CSM) analyses were conducted. RESULTS: The CSM results indicated that the present structural model could simulate bronchial occlusion. The CFD results showed that airflows from pressed lung alveoli might cause low-internal-pressure regions when suddenly or heterogeneously pushed airflow was injected from a small branching bronchus to a large bronchus. A preliminary computational mechanical model of bronchi was constructed. CONCLUSIONS: We demonstrated the performance of the mechanical model of bronchi in rough simulations of bronchial occlusions. However, this model should be verified further using human data to facilitate its introduction to clinical use.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5344737d694975d23f7f9f6ac1641a https://doi.org/10.3233/bme-211228 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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