Pathological lesions and presence of viral antigens in four surviving pigs in African swine fever outbreak farms in Vietnam
| Autor: | Nguyen Thi Hoa, Quang Lam Truong, Takuya Hirai, Phawut Nueangphuet, Uda Zahli Izzati, Mathurot Suwanruengsri, Apisit Pornthummawat, Nguyen Thi Lan, Ryoji Yamaguchi |
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| Rok vydání: | 2021 |
| Předmět: |
Farms
Genotype Swine Viral protein Sus scrofa animal disease survival Biology medicine.disease_cause Virus Disease Outbreaks Pathology medicine Animals Seroconversion contaminated carcasses Antigens Viral Pathological Gene Phylogeny Swine Diseases Lung Full Paper reparative process General Veterinary Stomach Outbreak Virology medicine.anatomical_structure Vietnam immunohistochemistry African swine fever |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | Investigation of the role of animals that have recovered and survived from African swine fever (ASF) in carrying the ASF virus is currently intense and ongoing. However, no clear definition of the carrier stage has been established. The aim of the present study was to establish criteria to elucidate a clear status of survival in naturally ASF-infected domestic pigs in Vietnam. Seroconversion from previous infection was confirmed by serological assay, and the absence of the viral genome in various organs was also assured by molecular analysis of a partial p72 gene. We recognized that histopathological evidence could benefit from further insights into the status and role of the surviving animals; therefore, we performed a histopathological study on four pigs from farms with a history of ASF outbreak. We found fibrotic changes in the reparative process as the main finding in all four pigs. Immunohistochemical detection of viral protein revealed an interesting result. Despite the negative result from viral genome detection, the p30 protein gave a positive signal in the tonsils, lung, and stomach. This raises the possibility of stress-induced viral reactivation in long-term survivors and the risk of further outbreaks from human handling of contaminated carcasses. |
| Databáze: | OpenAIRE |
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