In vivo dermal absorption of pyrethroid pesticides in the rat
| Autor: | Michael F. Hughes, Brenda C Edwards |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pyrethroid pesticides Dorsum Male Insecticides Adult male Health Toxicology and Mutagenesis Skin Absorption Bifenthrin 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Feces Animal science In vivo parasitic diseases Nitriles Pyrethrins medicine Animals Rats Long-Evans Tissue Distribution Permethrin 0105 earth and related environmental sciences integumentary system Chemistry Rats 030104 developmental biology Deltamethrin Isotope Labeling Body Burden medicine.drug |
| Zdroj: | Journal of toxicology and environmental health. Part A. 79(2) |
| ISSN: | 1528-7394 |
| Popis: | Exposure to pyrethroid pesticides is a potential cause for concern. The objective of this study was to examine the in vivo dermal absorption of bifenthrin, deltamethrin, and permethrin in the rat. Dorsal hair on adult male Long-Evans rats was removed. The next day, the skin was dosed with 1750 nmol (312.5 nmol/cm(2)) of radiolabeled (5 µCi) bifenthrin, deltamethrin, or permethrin in acetone. A nonoccluding plastic cover was glued over the dosing site. The animals were placed in metabolism cages to collect excreta. At 24 h postdosing, the skin was washed with soap and water, and rats in one group were euthanized and their tissues were collected. The skin was removed and tape stripped. The remaining animals were returned to the metabolism cages after the wash for 4 d. These rats were then euthanized and handled as already described. Excreta, wash, tape strips, tissues, and carcass were analyzed for pyrethroid-derived radioactivity. The wash and tape strips removed50% of the dose and skin retained 9-24%. Cumulative radioactivity in excreta was 0.5-7% at 24 h and 3-26% at 120 h. Radioactivity in tissues was0.3% of the dose, while carcass retained 2 to 5%. Assuming absorption equals cumulative recovery in skin (washed and tape stripped), excreta, tissues, and carcass, absorption was permethrin ~ bifenthrindeltamethrin at 24 h and permethrindeltamethrinbifenthrin at 120 h. Using the parallelogram approach with published in vitro data, human dermal absorption of these pyrethroids was estimated to be10% of the dose. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|