From Vaccines to Memory and Back
| Autor: | Koichi Araki, Federica Sallusto, Antonio Lanzavecchia, Rafi Ahmed |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
T-Lymphocytes
Immunology Disease Biology Immunological memory Article 03 medical and health sciences 0302 clinical medicine Immune system Antigen Immunity Humans Immunology and Allergy 030304 developmental biology B-Lymphocytes Vaccines 0303 health sciences Vaccination Antibodies Monoclonal Cell Differentiation Acquired immune system 3. Good health Infectious Diseases Drug Design biology.protein Antibody Immunologic Memory 030215 immunology |
| Zdroj: | Immunity Immunity; Vol 33 |
| ISSN: | 1074-7613 |
| Popis: | Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently, new methods have been developed to dissect the immune response in experimental animals and humans, which have led to increased understanding of the molecular mechanisms that control differentiation and maintenance of memory T and B cells. In this review we will provide an overview of the cellular organization of immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies. Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells-a journey from vaccines to memory and back. |
| Databáze: | OpenAIRE |
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