Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats
| Autor: | Ondrej Baďo, Jaroslav Hanuš, Lenka Paráková, Petra Šalamúnová, Jan Hošek, Ivan Saloň, Dominik Rotrekl, František Štěpánek |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Curcumin Polymers and Plastics Anti-Inflammatory Agents Inflammation 02 engineering and technology Saccharomyces cerevisiae 010402 general chemistry 01 natural sciences Beta-glucan Superoxide dismutase chemistry.chemical_compound Materials Chemistry medicine Animals Colitis Composite material Rats Wistar Glucans Glucan chemistry.chemical_classification Drug Carriers biology Interleukins Organic Chemistry Dextran Sulfate Interleukin 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Rats chemistry Myeloperoxidase biology.protein Cytokines medicine.symptom 0210 nano-technology |
| Zdroj: | Carbohydrate polymers. 252 |
| ISSN: | 1879-1344 |
| Popis: | The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue - tumor necrosis factor α (TNF-α), transforming growth factor β1, interleukin (IL)-1β, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin. |
| Databáze: | OpenAIRE |
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