Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring
| Autor: | Verena M. Link, Rose-Marie Karlsson, Jigar V. Desai, Han-Yu Shih, Ai Ing Lim, Oliver J. Harrison, Michail S. Lionakis, Heather A. Cameron, Seong-Ji Han, Taryn McFadden, Taylor K. Farley, Apollo Stacy, Djalma S. Lima-Junior, Yasmine Belkaid |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Offspring
Yersinia pseudotuberculosis Infections Context (language use) Inflammation Biology Article Epigenesis Genetic Fetal Development Epigenome Mice Immune system Pregnancy T-Lymphocyte Subsets Immunity medicine Animals Intestinal Mucosa Pregnancy Complications Infectious Salmonella Infections Animal Fetus Multidisciplinary Interleukin-6 Stem Cells Candidiasis Colitis medicine.disease Chromatin Gastrointestinal Microbiome Intestines Prenatal Exposure Delayed Effects Immunology Th17 Cells Female medicine.symptom |
| Zdroj: | Science |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Mom’s IL-6 rewires baby’s gut immunity Most infections that occur during pregnancy are mild and transient. However, whether such pathogen encounters can shape the long-term trajectory of the offspring’s immune system remains unclear. Lim et al . infected pregnant mice with the common food-borne pathogen Yersinia pseudotuberculosis (YopM) (see the Perspective by Amir and Zeng). Although the infection was maternally restricted and short-lived, the offspring harbored greater numbers of intestinal T helper 17 cells into adulthood. Interleukin-6 (IL-6) mediated this tissue-restricted effect by acting on fetal intestinal epithelium during development. Although offspring from mothers infected with YopM or injected with IL-6 showed enhanced resistance to oral infection with Salmonella Typhimurium, they also exhibited higher susceptibility toward enteric inflammatory disease. —STS |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|