Cerebellar metastasis of gastrointestinal stromal tumor: A case report and review of the literature
| Autor: | Mohamed Badri, Ghassen Gader, Kamel Bahri, Mohamed Chabaane, Ihsen Zammel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Abdominal pain Stromal cell medicine.medical_treatment Neurosurgery Peritonitis Case Report Article Metastasis 03 medical and health sciences Posterior fossa 0302 clinical medicine medicine Stromal tumor Craniotomy business.industry digestive oral and skin physiology medicine.disease digestive system diseases Radiation therapy 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Radiology medicine.symptom business |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| Popis: | Highlights • Brain metastases are rare forms of manifestations of gastro-intestinal stromal tumors. • Brain metastases of gastro-intestinal stromal tumors are usually supra-tentorial. Infra-tentorial localizations are very rare. • The treatment is based on surgery and radiotherapy. Chemotherapy has only limited interest. Introduction Intracranial metastases of gastro intestinal tumors are very rare. To the best of our knowledge only few cases were reported on the literature. Case description We describe the case of 66-year-old male that presented with headache and vomiting. Physical examination found a kinetic cerebellar syndrome. Brain CT scan and MRI showed a right cerebellar tumor. Sub-occipital craniotomy was performed and the tumor was completely resected. Surgical outcomes were marked by the occurrence of an abdominal pain two days after brain surgery. Peritonitis was diagnosed and the patient underwent surgery. Per-operatively, a hemorrhagic tumor perforating the intestines was found and resected. Pathologic examination of the cerebral tumor's resection piece and the intestinal resection piece concluded to a metastasis of a stromal gastro-intestinal tumor. Discussion Gastro-intestinal stromal tumors are frequent neoplasms, but intracranial metastases of these neoplasms are extremely rare. Abdominal symptomatology frequently reveals the pathology. However, extra digestive symptoms may in rare cases disclose intestinal tumors. Intracranial metastases of gastro-intestinal stromal tumors are generally solitary mainly supratentorial. Infratentorial metastases are very uncommon. Management of gastro-intestinal stromal tumors is based on surgical removal of the tumor. Adjuvant treatment consisting on chemotherapy and radiotherapy is subject of debate. Conclusions Gastro-intestinal stromal tumors are frequent neoplasms with a high metastasizing potential on liver and peritoneum. Brain metastases are extremely rare and the prognosis is worse when they are present. Surgery remains the main treatment for the primitive and the secondary lesions. |
| Databáze: | OpenAIRE |
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