Ultrasensitive detection of inhaled organic aerosol particles by accelerator mass spectrometry
| Autor: | S.A. Rastigeev, Aleksey G. Okunev, P.N. Kalinkin, Victoria S. Semeykina, T.A. Trubitsyna, K.A. Sashkina, A.I. Taratayko, V.A. Reznikov, I.V. Voronova, A.V. Selivanova, Ekaterina V. Parkhomchuk, V.V. Parkhomchuk, A.M. Baklanov, D.G. Gulevich |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Environmental Engineering Health Toxicology and Mutagenesis Analytical chemistry Emulsion polymerization 010501 environmental sciences Kidney Mass spectrometry 01 natural sciences Mass Spectrometry Styrene 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Administration Inhalation Animals Environmental Chemistry Carbon Radioisotopes Particle Size Lung 0105 earth and related environmental sciences Aerosols Radiochemistry Public Health Environmental and Occupational Health Brain General Medicine General Chemistry Penetration (firestop) Pollution Aerosol Liver 030228 respiratory system chemistry Mice Inbred CBA Polystyrenes Polystyrene Particle size Accelerator mass spectrometry |
| Zdroj: | Chemosphere. 159:80-88 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2016.05.078 |
| Popis: | Accelerator mass spectrometry (AMS) was shown to be applicable for studying the penetration of organic aerosols, inhaled by laboratory mice at ultra-low concentration ca. 10(3) cm(-3). We synthesized polystyrene (PS) beads, composed of radiocarbon-labeled styrene, for testing them as model organic aerosols. As a source of radiocarbon we used methyl alcohol with radioactivity. Radiolabeled polystyrene beads were obtained by emulsifier-free emulsion polymerization of synthesized (14)C-styrene initiated by K2S2O8 in aqueous media. Aerosol particles were produced by pneumatic spraying of diluted (14)C-PS latex. Mice inhaled (14)C-PS aerosol consisting of the mix of 10(3) 225-nm particles per 1 cm(3) and 5·10(3) 25-nm particles per 1 cm(3) for 30 min every day during five days. Several millions of 225-nm particles deposited in the lungs and slowly excreted from them during two weeks of postexposure. Penetration of particles matter was also observed for liver, kidneys and brain, but not for a heart. |
| Databáze: | OpenAIRE |
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