Tonic immobility in domestic fowl: possible interaction of serotonergic and dopaminergic mechanisms
| Autor: | Philip Corso, Gerard D. Bordash, Larry B. Wallnau |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Agonist
medicine.medical_specialty Apomorphine medicine.drug_class Fenfluramine Clinical Biochemistry Toxicology Serotonergic Biochemistry Tonic (physiology) Receptors Dopamine Behavioral Neuroscience Immobilization Dopamine Internal medicine medicine Animals Humans Biological Psychiatry Pharmacology Catalepsy Chemistry Dopaminergic Tryptophan Endocrinology Receptors Serotonin Haloperidol Serotonin Chickens medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 14(4) |
| ISSN: | 0091-3057 |
| Popis: | Treatment with the dopamine (DA) receptor blocker, haloperidol, enhanced tonic immobility (TI) duration. Fenfluramine, a receptor agonist for serotonin (5-HT), reversed this effect. Tryptophan produced long TI reactions, and is believed to do so due to impaired synaptic transmission of 5-HT following its direct inhibitory effects on 5-HT neurons. DA receptor stimulation by apomorphine prevented the tryptophan potentiation of tonic immobility. The results suggest that serotonergic and dopaminergic systems may interact with respect to tonic immobility. |
| Databáze: | OpenAIRE |
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