Risk factors for osteonecrosis of the jaws: a case-control study from the CONDOR dental PBRN
| Autor: | Barasch, A., Joana Cunha-Cruz, Curro, F. A., Hujoel, P., Sung, A. H., Vena, D., Voinea-Griffin, A. E., Steven Beadnell, Craig, Ronald G., Timothy DeRouen, Ananda Desaranayake, Ann Gilbert, Gregg Gilbert, Ken Goldberg, Richard Hauley, Mariko Hashimoto, Jon Holmes, Brooke Latzke, Brian Leroux, Anne Lindblad, Joshua Richman, Monika Safford, Jonathan Ship, Thompson, P., Dale Williams, O., Yin Wanrong |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Community-Based Participatory Research Time Factors medicine.medical_treatment Osteoporosis Dentistry Administration Oral Logistic regression Diabetes Complications Risk Factors Neoplasms medicine Humans Risk factor General Dentistry Suppuration Bone Density Conservation Agents Diphosphonates Radiotherapy business.industry Smoking Case-control study Age Factors Osteonecrosis Research Reports Anemia Odds ratio Bisphosphonate Middle Aged medicine.disease Dental extraction Case-Control Studies Chronic Disease Injections Intravenous Tooth Extraction Income Educational Status Female business Gingival Hemorrhage Jaw Diseases Cohort study |
| Zdroj: | University of Alabama at Birmingham-Profiles |
| ISSN: | 1544-0591 |
| Popis: | Case reports and cohort studies have linked bisphosphonate therapy and osteonecrosis of the jaws (ONJ), but neither causality nor specific risks for lesion development have been clearly established. We conducted a 1:3 case-control study with three dental Practice-based Research Networks, using dentist questionnaires and patient interviews for collection of data on bisphosphonate therapy, demographics, co-morbidities, and dental and medical treatments. Multivariable logistic regression analyses tested associations between bisphosphonate use and other risk factors with ONJ. We enrolled 191 ONJ cases and 573 controls in 119 dental practices. Bisphosphonate use was strongly associated with ONJ (odds ratios [OR] 299.5 {95%CI 70.0-1282.7} for intravenous [IV] use and OR = 12.2 {4.3-35.0} for oral use). Risk markers included local suppuration (OR = 7.8 {1.8-34.1}), dental extraction (OR = 7.6 {2.4-24.7}), and radiation therapy (OR = 24.1 {4.9-118.4}). When cancer patients (n = 143) were excluded, bisphosphonate use (OR = 7.2 {2.1-24.7}), suppuration (OR = 11.9 {2.0-69.5}), and extractions (OR = 6.6 {1.6-26.6}) remained associated with ONJ. Higher risk of ONJ began within 2 years of bisphosphonate initiation and increased four-fold after 2 years. Both IV and oral bisphosphonate use were strongly associated with ONJ. Duration of treatment > 2 years; suppuration and dental extractions were independent risk factors for ONJ. |
| Databáze: | OpenAIRE |
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