inter- and intrahemispheric dissociations in ideomotor apraxia: a large-Scale lesion–symptom mapping study in subacute brain-damaged patients
| Autor: | Jean-Marie Annoni, Leila Chouiter, Lucas Spierer, Narges Radman, Stephanie Clarke, Aurélie L. Manuel, Delphine Mesot |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Cerebral Cortex/pathology/physiopathology Dissociation (neuropsychology) Adolescent Cognitive Neuroscience Audiology computer.software_genre Brain mapping 050105 experimental psychology Lateralization of brain function Functional Laterality Lesion 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult 0302 clinical medicine Voxel Functional neuroimaging Parietal Lobe medicine Frontal Lobe/pathology/physiopathology Humans 0501 psychology and cognitive sciences Stroke Aged Aged 80 and over Cerebral Cortex Brain Damage Chronic/pathology/physiopathology Brain Mapping 05 social sciences Apraxia Ideomotor/pathology/physiopathology Apraxia Ideomotor Ideomotor apraxia Middle Aged medicine.disease Imitative Behavior Magnetic Resonance Imaging Frontal Lobe Apraxia Ideomotor/pathology Apraxia Ideomotor/physiopathology Brain Damage Chronic/pathology Brain Damage Chronic/physiopathology Cerebral Cortex/pathology Cerebral Cortex/physiopathology Female Frontal Lobe/pathology Frontal Lobe/physiopathology Parietal Lobe/pathology Parietal Lobe/physiopathology Parietal Lobe/pathology/physiopathology Brain Damage Chronic medicine.symptom Psychology computer 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Cerebral Cortex, vol. 23, no. 12, pp. 2781-2789 Cerebral Cortex Cerebral Cortex, Vol. 23, No 12 (2013) pp. 2781-9 |
| ISSN: | 1047-3211 |
| Popis: | Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior frontal areas, suggesting that defective selection of movement features is the cause of pantomime errors. We conducted a large-scale voxel-based lesion-symptom mapping analyses with configural/spatial (CS) and body-part-as-object (BPO) pantomime errors of 150 left and right brain-damaged patients. Our results confirm the left hemisphere dominance in pantomime. Both types of error were associated with damage to left inferior frontal regions in tumor and stroke patients. While CS pantomime errors were associated with left temporoparietal lesions in both stroke and tumor patients, these errors appeared less associated with parietal areas in stroke than in tumor patients and less associated with temporal in tumor than stroke patients. BPO errors were associated with left inferior frontal lesions in both tumor and stroke patients. Collectively, our results reveal a left intrahemispheric dissociation for various aspects of pantomime, but with an unspecific role for inferior frontal regions. |
| Databáze: | OpenAIRE |
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