Serosurveillance of Coxiellosis (Q-fever) and Brucellosis in goats in selected provinces of Lao People’s Democratic Republic

Autor: Stuart D. Blacksell, Rebekah J. L. Burns, Syseng Khounsy, Matthew D. Wegner, Bounlom Douangngeun, Mavuto Mukaka, Peter A. Windsor, Paul Selleck, Eric Hansson, Watthana Theppangna
Rok vydání: 2018
Předmět:
Bacterial Diseases
Male
Veterinary medicine
Pathology and Laboratory Medicine
0403 veterinary science
0302 clinical medicine
Risk Factors
Seroepidemiologic Studies
Zoonoses
Direct agglutination test
Medicine and Health Sciences
Enzyme-Linked Immunoassays
Mammals
2. Zero hunger
Goat Diseases
biology
Goats
lcsh:Public aspects of medicine
Eukaryota
Agriculture
Ruminants
04 agricultural and veterinary sciences
Breed
Bacterial Pathogens
3. Good health
Infectious Diseases
Veterinary Diseases
Medical Microbiology
Coxiella burnetii
Laos
Vertebrates
Female
Livestock
Pathogens
Q Fever
Research Article
Neglected Tropical Diseases
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
040301 veterinary sciences
030231 tropical medicine
Enzyme-Linked Immunosorbent Assay
Q fever
Brucella
Research and Analysis Methods
Microbiology
Brucellosis
03 medical and health sciences
medicine
Animals
Humans
Immunoassays
Microbial Pathogens
Bacteria
business.industry
Organisms
Public Health
Environmental and Occupational Health
Biology and Life Sciences
lcsh:RA1-1270
Tropical Diseases
bacterial infections and mycoses
biology.organism_classification
medicine.disease
Amniotes
Immunologic Techniques
Veterinary Science
business
Zdroj: PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006411 (2018)
PLoS Neglected Tropical Diseases
ISSN: 1935-2735
Popis: Goat raising is a growing industry in Lao People’s Democratic Republic, with minimal disease investigation to date, especially zoonoses. This study determined the proportional seropositivity of two zoonotic diseases: Q fever (causative agent Coxiella burnetii) and Brucellosis (Brucella species) in goats across five provinces (Vientiane Capital, Xayaboury, Xiengkhuang, Savannakhet and Attapeu). A total of 1458 goat serum samples were tested using commercial indirect ELISA for both pathogens, plus Rose Bengal agglutination test for Brucellosis. Overall individual seropositivity of C. burnetii was 4.1% and Brucella spp. was 1.4%. A multiple logistic regression model identified that province (Vientiane Capital, p = 0.05), breed (introduced Boer mixed breed, p = 0.006) and age (goats ≥3 years old, p = 0.014) were significant risk factors for C. burnetii seropositivity. The results of the survey indicated that province (Vientiane Capital, p
Author summary Goat raising is a growing industry in Lao People’s Democratic Republic however there is very little information whether or not goat raising poses a disease threat to farmers and the general population through diseases that may be transmitted between animals and humans (i.e., zoonotic diseases). To determine this, we tested goats for antibodies against two zoonotic diseases: Q fever (causative agent Coxiella burnetii) and Brucellosis (Brucella species) in Lao goats across five provinces (Vientiane Capital, Xayaboury, Xiengkhuang, Savannakhet and Attapeu). The presence of antibodies does not necessarily indicate active disease but that animals have been previously exposed to Q fever and Brucellosis. A total of 1458 goat serum samples were tested and the overall antibody positivity of the goats for C. burnetii was 4.1% and Brucella spp. was 1.4%. The highest risk of having Q fever antibodies was the goats being based in Vientiane Capital, of Boer mixed breed and ≥3 years old. The highest risk of having Brucella spp. antibodies was being based in Vientiane Capital, of Boer mixed breed as well as factors related to production system, age, and farm size. There is an urgent need to determine human health risks and economic losses caused by Q fever and Brucellosis.
Databáze: OpenAIRE
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