The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm

Autor: Emily Neger, Sophy Kim, Jennifer Benjamin, Aimee Asgarian, Debbie Allred, Julie Rathbun, Rachel Wilson, Echo Meyer, Karl C.K. Kuban, Kirsten McGhee, Anjali Sadhwani, Ann Foley, Barbara Prendergast, Michael E. Msall, Jackie Friedman, Ellen C. Perrin, Brandi Henson, Kathy Tsatsanis, Patricia Lee, Janice Ware, Gary Stainback, Susan McQuiston, Judith Klarr, Deborah Klein, Jill Damon-Minow, Rugile Ramoskaite, Ellen Waldrep, Brian Dessureau, Jenifer Walkowiak, Krissy Washington, Janice Bernhardt, Nancy Darden-Saad, Jean A. Frazier, Scott J. Hunter, Bhavesh Shah, T. Michael O'Shea, Deborah Weiland, Thomas M. O'Shea, Timothy Heeren, Diane Warner, Beth Powers, Elizabeth N. Allred, Laurie M. Douglass, Lauren Venuti, Rachana Singh, Elizabeth T. Jensen, Sarah Nota, Kathryn Mattern, Nancy Peters, Suzanne Wiggins, Megan Lloyd, Jennifer DeRidder, Julie Vanier Rollins, Steve Pastyrnak, Teri Crumb, Susan Barron, Joni McKeeman, Anne Smith, Katarzyna Chawarska, Patricia Brown, Janice Wereszczak, Richard A. Ehrenkranz, Susan Dieterich, Emily Ansusinha, Molly Wood, Jelske W. van der Burg, Wendy Burdo-Hartman, Elaine Romano, Karen Bearrs, Kelly Vogt, Beth Kring, Taryn Coster, Ryan Martin, Robert M. Joseph, Alan Leviton, Megan Scott, Madeleine Lenski, Gail Hounshell, Stephen C. Engelke
Přispěvatelé: E&H: Environmental Health and Toxicology
Rok vydání: 2016
Předmět:
Zdroj: Journal of Pediatrics, 187, 50-57.e3. Mosby Inc.
Jensen, E T, van der Burg, J W, O'Shea, T M, Joseph, R M, Allred, E N, Heeren, T, Leviton, A, Kuban, K C K & Extremely Low Gestational Age Newborns Study Investigators 2017, ' The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm ', Journal of Pediatrics, vol. 187, pp. 50-57.e3 . https://doi.org/10.1016/j.jpeds.2017.02.064
ISSN: 1097-6833
0022-3476
DOI: 10.1016/j.jpeds.2017.02.064
Popis: OBJECTIVE: To assess the association between maternal prepregnancy body mass index and adequacy of pregnancy weight gain in relation to neurocognitive function in school-aged children born extremely preterm.STUDY DESIGN: Study participants were 535 ten-year-old children enrolled previously in the prospective multicenter Extremely Low Gestational Age Newborns cohort study who were products of singleton pregnancies. Soon after delivery, mothers provided information about prepregnancy weight. Prepregnancy body mass index and adequacy of weight gain were characterized based on this information. Children underwent a neurocognitive evaluation at 10 years of age.RESULTS: Maternal prepregnancy obesity was associated with increased odds of a lower score for Differential Ability Scales-II Verbal IQ, for Developmental Neuropsychological Assessment-II measures of processing speed and visual fine motor control, and for Wechsler Individual Achievement Test-III Spelling. Children born to mothers who gained an excessive amount of weight were at increased odds of a low score on the Oral and Written Language Scales Oral Expression assessment. Conversely, children whose mother did not gain an adequate amount of weight were at increased odds of a lower score on the Oral and Written Language Scales Oral Expression and Wechsler Individual Achievement Test-III Word Reading assessments.CONCLUSION: In this cohort of infants born extremely preterm, maternal obesity was associated with poorer performance on some assessments of neurocognitive function. Our findings are consistent with the observational and experimental literature and suggest that opportunities may exist to mitigate risk through education and behavioral intervention before pregnancy.
Databáze: OpenAIRE