Combinational Effects of Prebiotics and Soybean against Azoxymethane-Induced Colon Cancer In Vivo
| Autor: | L. Shackelford, Martha Verghese, N. K. Bhat, J. Boateng, V. P. Gourineni, Lloyd T. Walker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Nutrition and Dietetics Article Subject business.industry Azoxymethane Colorectal cancer Endocrinology Diabetes and Metabolism Prebiotic medicine.medical_treatment Soybean meal Pharmacology Isoflavones medicine.disease Acclimatization chemistry.chemical_compound lcsh:Nutritional diseases. Deficiency diseases Fructan chemistry In vivo Medicine business lcsh:RC620-627 Food Science Research Article |
| Zdroj: | Journal of Nutrition and Metabolism, Vol 2011 (2011) Journal of Nutrition and Metabolism |
| ISSN: | 2090-0732 2090-0724 |
| Popis: | Prebiotic fructans are nondigestible carbohydrates with numerous health benefits. Soybean is a rich source of phytonutrients such as isoflavones. The objective of this study was to evaluate the chemopreventive effects of prebiotics (Synergy1) and soybean meal (SM) at 5% and 10% levels alone and in combination on azoxymethane- (AOM-) induced colon carcinogenesis. After one wk of acclimatization, Fisher 344 male rats (N=90) were randomly assigned to 9 groups (n=10). Control rats (C) were fed AIN-93G/M. Two s/c injections of AOM were administered to rats at 7 and 8 wk of age at 16 mg/kg body weight. Rats were killed by CO2asphyxiation at 45 wk. Tumor incidence (%) in treatment groups ranged from 40 to 75 compared to 100 in C. Results indicate that feeding prebiotics and soybean in combination significantly reduced incidence of AOM-induced colon tumors with implications for food industry in the food-product development. |
| Databáze: | OpenAIRE |
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