Factor Xa inhibitors differently modulate electrical activities in pulmonary veins and the sinoatrial node
| Autor: | Jen Hung Huang, Satoshi Higa, Chien Jung Chang, Shih Ann Chen, Chen Chuan Cheng, Yao Chang Chen, Yi Jen Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Patch-Clamp Techniques medicine.drug_mechanism_of_action Pyridines Factor Xa Inhibitor Action Potentials 030204 cardiovascular system & hematology Guanidines Sodium-Calcium Exchanger Pulmonary vein 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rivaroxaban Ranolazine Edoxaban Internal medicine Atrial Fibrillation Animals Medicine Myocytes Cardiac Receptor PAR-1 Stroke Sinoatrial Node Pharmacology business.industry Sinoatrial node Atrial fibrillation medicine.disease Thiazoles Electrophysiology 030104 developmental biology medicine.anatomical_structure chemistry Pulmonary Veins Models Animal cardiovascular system Cardiology Rabbits business Microelectrodes Oligopeptides Factor Xa Inhibitors medicine.drug |
| Zdroj: | European Journal of Pharmacology. 833:462-471 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2018.07.003 |
| Popis: | Factor Xa inhibitors reduce stroke in patients with atrial fibrillation. Pulmonary veins (PVs) and the sinoatrial node (SAN) are crucial for genesis of atrial fibrillation. However, the electrophysiological effects of factor Xa inhibitors (edoxaban and rivaroxaban) on PVs and the SAN remain unclear. Conventional microelectrodes were used to record the action potential in isolated rabbit PVs and SAN preparations before and after administration of edoxaban (0.1, 0.3, and 1 μM) or rivaroxaban (0.01, 0.03, 0.1, and 0.3 μM). A whole-cell patch-clamp was used to record the late sodium current (INa-late) in isolated single rabbit PV cardiomyocytes. Edoxaban significantly reduced PV spontaneous beating rates at 0.3 and 1 μM (N = 6 rabbits, P |
| Databáze: | OpenAIRE |
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