Mechanical properties of the drug-eluting bioresorbable magnesium scaffold compared with polymeric scaffolds and a permanent metallic drug-eluting stent

Autor: Niels Ramsing Holm, John A. Ormiston, Bruce Webber, Trine Ørhøj Barkholt
Rok vydání: 2019
Předmět:
Scaffold
medicine.medical_treatment
Coronary Artery Disease
030204 cardiovascular system & hematology
mechanical properties
Balloon
chemistry.chemical_compound
Cardiologists
0302 clinical medicine
Basic Science
Coated Materials
Biocompatible

Absorbable Implants
Materials Testing
Medicine
Magnesium
030212 general & internal medicine
Angioplasty
Balloon
Coronary

stenting technique
Drug-Eluting Stents
General Medicine
Prosthesis Failure
Treatment Outcome
Pharmaceutical Preparations
Metallic drug
Cardiology and Cardiovascular Medicine
Cardiology
chemistry.chemical_element
Prosthesis Design
strut fracture
03 medical and health sciences
Silicone
Side branch
Humans
Radiology
Nuclear Medicine and imaging

bioresorbable scaffolds
business.industry
fungi
percutaneous coronary intervention
Stent
Cardiovascular Agents
Equipment Failure Analysis
chemistry
stent
Stress
Mechanical

business
bifurcations
Bioresorbable scaffold
Biomedical engineering
Zdroj: Barkholt, T, Webber, B, Holm, N R & Ormiston, J A 2020, ' Mechanical properties of the drug-eluting bioresorbable magnesium scaffold compared with polymeric scaffolds and a permanent metallic drug-eluting stent ', Catheterization and Cardiovascular Interventions, vol. 96, no. 7, pp. E674-E682 . https://doi.org/10.1002/ccd.28545
Catheterization and Cardiovascular Interventions
ISSN: 1522-726X
DOI: 10.1002/ccd.28545
Popis: Objectives: To compare on the bench the physical and mechanical properties of Magmaris, a magnesium bioresorbable scaffold (BRS), with Absorb and DESolve polymeric BRS and a permanent metallic stent. Background: Understanding the mechanical and physical properties of BRS is crucial for appropriate implantation and postdilatation. Methods: Testing was performed in fluid at 37°C and in silicone bifurcation phantoms with a 30° angle between main branch (MB) and side branch. Results: The 3.0-mm Magmaris BRS did not fracture after MB postdilatation up to 4.4 mm in contrast to the Absorb where the safe postdilatation diameter was 3.7 mm. For dilatation through stent cells, there were no Magmaris fractures with 3.0-mm noncompliant (NC) balloons inflated to nominal pressure. Mini-kissing balloon postdilatation with two 3.0-mm NC balloons up to 17 atm was without fracture except for an outlier. Longitudinal and radial strengths were similar for Magmaris and Absorb BRS. The crossing profile for the Magmaris was larger than other devices. Recoil 120 min after deployment was the greatest for Magmaris but 120 min after 3.5 mm postdilatation all devices had similar diameters. Conclusions: The Magmaris BRS was more resistant to strut fracture than Absorb. It had a larger crossing profile than other devices and similar radial and longitudinal strengths to Absorb. While recoil after deployment was greater with Magmaris, 120 min after 3.5 mm postdilatation all devices had similar diameters.
Databáze: OpenAIRE