Mechanical properties of the drug-eluting bioresorbable magnesium scaffold compared with polymeric scaffolds and a permanent metallic drug-eluting stent
Autor: | Niels Ramsing Holm, John A. Ormiston, Bruce Webber, Trine Ørhøj Barkholt |
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Rok vydání: | 2019 |
Předmět: |
Scaffold
medicine.medical_treatment Coronary Artery Disease 030204 cardiovascular system & hematology mechanical properties Balloon chemistry.chemical_compound Cardiologists 0302 clinical medicine Basic Science Coated Materials Biocompatible Absorbable Implants Materials Testing Medicine Magnesium 030212 general & internal medicine Angioplasty Balloon Coronary stenting technique Drug-Eluting Stents General Medicine Prosthesis Failure Treatment Outcome Pharmaceutical Preparations Metallic drug Cardiology and Cardiovascular Medicine Cardiology chemistry.chemical_element Prosthesis Design strut fracture 03 medical and health sciences Silicone Side branch Humans Radiology Nuclear Medicine and imaging bioresorbable scaffolds business.industry fungi percutaneous coronary intervention Stent Cardiovascular Agents Equipment Failure Analysis chemistry stent Stress Mechanical business bifurcations Bioresorbable scaffold Biomedical engineering |
Zdroj: | Barkholt, T, Webber, B, Holm, N R & Ormiston, J A 2020, ' Mechanical properties of the drug-eluting bioresorbable magnesium scaffold compared with polymeric scaffolds and a permanent metallic drug-eluting stent ', Catheterization and Cardiovascular Interventions, vol. 96, no. 7, pp. E674-E682 . https://doi.org/10.1002/ccd.28545 Catheterization and Cardiovascular Interventions |
ISSN: | 1522-726X |
DOI: | 10.1002/ccd.28545 |
Popis: | Objectives: To compare on the bench the physical and mechanical properties of Magmaris, a magnesium bioresorbable scaffold (BRS), with Absorb and DESolve polymeric BRS and a permanent metallic stent. Background: Understanding the mechanical and physical properties of BRS is crucial for appropriate implantation and postdilatation. Methods: Testing was performed in fluid at 37°C and in silicone bifurcation phantoms with a 30° angle between main branch (MB) and side branch. Results: The 3.0-mm Magmaris BRS did not fracture after MB postdilatation up to 4.4 mm in contrast to the Absorb where the safe postdilatation diameter was 3.7 mm. For dilatation through stent cells, there were no Magmaris fractures with 3.0-mm noncompliant (NC) balloons inflated to nominal pressure. Mini-kissing balloon postdilatation with two 3.0-mm NC balloons up to 17 atm was without fracture except for an outlier. Longitudinal and radial strengths were similar for Magmaris and Absorb BRS. The crossing profile for the Magmaris was larger than other devices. Recoil 120 min after deployment was the greatest for Magmaris but 120 min after 3.5 mm postdilatation all devices had similar diameters. Conclusions: The Magmaris BRS was more resistant to strut fracture than Absorb. It had a larger crossing profile than other devices and similar radial and longitudinal strengths to Absorb. While recoil after deployment was greater with Magmaris, 120 min after 3.5 mm postdilatation all devices had similar diameters. |
Databáze: | OpenAIRE |
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