Vincristine-induced neurotoxicity in pediatric patients with rhabdomyosarcoma: A retrospective analysis of clinical features and outcome

Autor:	Lama Dakik, Maya Basbous, Hani Tamim, Yacoub Moubarak, Nidale Tarek, Dima Hamideh, Samar Muwakkit, Miguel Abboud, Raya Saab
Rok vydání:	2022
Předmět:	Oncology Vincristine Antineoplastic Combined Chemotherapy Protocols Rhabdomyosarcoma Pediatrics Perinatology and Child Health Humans Neurotoxicity Syndromes Rhabdomyosarcoma Embryonal Hematology Neoplasm Recurrence Local Child Retrospective Studies
Zdroj:	Pediatric Hematology and Oncology. 39:644-649
ISSN:	1521-0669 0888-0018
DOI:	10.1080/08880018.2022.2047849
Popis:	Vincristine is an essential component of rhabdomyosarcoma treatment. However, it can cause motor neurotoxicity, necessitating dose reductions. We retrospectively reviewed the rates and patterns of vincristine-induced motor neuropathy in children treated for rhabdomyosarcoma, and investigated effects on outcome. Fifteen of 43 patients (35%) developed motor neuropathies necessitating dose reductions, which ranged from 1.7% to 58% of planned cumulative dose. Older age was the only significant clinical risk factor. Almost half (47%) recovered during treatment with subsequent dose escalation. Most patients had complete resolution of symptoms upon follow-up. There was no discernible effect of treatment reduction on survival or relapse rates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4859ddfdfd37fa66e9be3163f556ed https://doi.org/10.1080/08880018.2022.2047849 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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