Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

Autor:	Edson X. Albuquerque, François Noël, V.P. Rodrigues, Daniele V de Souza, Flávia V. Brito, Elisa Suzana Carneiro Pôças, Alcides J. M. da Silva, Paulo R. R. Costa, Noelson M.V Silva, Paulo A. Melo, Camilla D. Buarque
Rok vydání:	2001
Předmět:	Stereochemistry Clinical Biochemistry Pharmaceutical Science Flunitrazepam Resorcinol Biochemistry Chemical synthesis NA K EXCHANGING ATPASE Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Coumarins Crotalid Venoms Drug Discovery Animals Combinatorial Chemistry Techniques Bothrops Enzyme Inhibitors GABA Modulators Creatine Kinase Molecular Biology chemistry.chemical_classification Dose-Response Relationship Drug biology Plant Extracts Chemistry Organic Chemistry Biological activity Oxygenation Rats Oxygen Anti-Anxiety Agents Enzyme inhibitor biology.protein Molecular Medicine Sodium-Potassium-Exchanging ATPase Lactone Synaptosomes
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:283-286
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(00)00621-1
Popis:	Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound ( 2b , IC 50 =1 μM) was selected for study of its pharmacological profile.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4829b21581fef9b7a152d3ec996662 https://doi.org/10.1016/s0960-894x(00)00621-1 Zobrazit plný text záznamu Full Text from ScienceDirect