Evaluating the Efficacy of Therapies in Patients With Coronavirus Disease 2019
| Autor: | Joseph J. Eron, Donglin Zeng, Danyu Lin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
2019-20 coronavirus outbreak medicine.medical_specialty Coronavirus disease 2019 (COVID-19) business.industry Clinical events Surrogate endpoint Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Clinical course 030204 cardiovascular system & hematology Clinical trial 03 medical and health sciences 0302 clinical medicine Infectious Diseases Medicine In patient 030212 general & internal medicine business Intensive care medicine |
| Zdroj: | Clinical Infectious Diseases |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | There is a proliferation of clinical trials worldwide to find effective therapies for patients diagnosed with coronavirus disease 2019 (COVID-19). The endpoints that are currently used to evaluate the efficacy of therapeutic agents against COVID-19 are focused on clinical status at a particular day or on time to a specific change of clinical status. To provide a full picture of the clinical course of a patient and make complete use of available data, we consider the trajectory of clinical status over the entire follow-up period. We also show how to combine the evidence of treatment effects on the occurrences of various clinical events. We compare the proposed and existing endpoints through extensive simulation studies. Finally, we provide guidelines on establishing the benefits of treatments. |
| Databáze: | OpenAIRE |
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